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Chronic Obstructive Pulmonary Disease Gene Localization Clinical Trials References presented on Clinical Trials Search is not intended to be a substitute for proven healthcare advice, trips or professional assistance by using a real medical. We aren't mDs. Always confer with your physician about Chronic Obstructive Pulmonary Disease Gene Localization conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. Chronic Obstructive Pulmonary Disease Gene Localization Clinical research trials and Chronic Obstructive Pulmonary Disease Gene Localization medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the effectualness of new does drugs. The purpose of the studies / projects is to solve specific human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to discover treatments for all sorts of conditions, such as Chronic Obstructive Pulmonary Disease Gene Localization. Chronic Obstructive Pulmonary Disease Gene Localization Clinical Trials and other clinical trials permit volunteers to access healthcare treatment choices before they are available to the general public. Some times the subjects recieve professional assistance for without cost, and every now and again they are compensated for their time. Sometimes there is a cost for a Chronic Obstructive Pulmonary Disease Gene Localization clinical trial. Subjects often receive the most expert healthcare possible for their Chronic Obstructive Pulmonary Disease Gene Localization condition. Risks are a reality, nevertheless, and could include additional or frequent dr. calls, healthcare dangers (perhaps life-jeopardising), and/or the treatment being ineffective. Trials are federally governed with stern guidelines to protect clinical trials subjects.
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Home > "C" Clinical Trials Conditions > Chronic Obstructive Pulmonary Disease Gene Localization  Chronic Obstructive Pulmonary Disease Gene Localization
Chronic Obstructive Pulmonary Disease Gene Localization
For Condition: Lung Diseases,Chronic Obstructive Pulmonary Disease
Status: No longer recruiting
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To localize within the genome a chronic obstructive pulmonary disease susceptibility gene.
Details: BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a slowly progressive disorder characterized by airways obstruction that lasts for at least several months. The two major causes of COPD are chronic bronchitis and emphysema. Either disorder may occur with or without airways obstruction, but airways obstruction causes impairment of lung function leading to disability and death. COPD is a major health problem in the United States and throughout the world, consistently ranking among the most common causes of death in the United States. Cigarette smoking is the primary environmental factor that increases the risk of COPD, but other environmental factors have also been implicated. However, despite a well-established role, environmental factors alone do not cause COPD. Symptomatic COPD develops in only 10-20 percent of heavy cigarette smokers, probably those with a genetic susceptibility, although common COPD susceptibility genes have yet to be identified. DESIGN NARRATIVE: The study applies statistical linkage analysis to family data. Pulmonary measurements have already been collected on 159 members of 16 pedigrees and evidence supporting a COPD susceptibility gene in these pedigrees has been obtained from segregation analysis. Each of 11,995 genetic markers, which have already been genotyped on pedigree members, will be tested for evidence of linkage to the inferred COPD susceptibility gene. Evidence of linkage to one or more genetic markers will identify genomic locations of COPD susceptibility genes. The high density of markers will allow fine-mapping of the gene. Successful completion of this gene localization project is the necessary prerequisite for a project to identify and characterize a COPD susceptibility gene. Identifying a gene that when mutated increases the risk of COPD may increase understanding of pulmonary function, as well as allowing gene-carriers to be identified and made aware of their susceptibility.
Eligibility:
Study Type: Observational, Natural History, Defined Population
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: No eligibility criteria
Total Enrollment:
Location and Contact Information:
Overall Study Official:
SandraHasstedt, , University of Utah
Additional Information:
Study ID Numbers: 1175;
Study Start Date: April 2001
Record last reviewed: January 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00037739
Other Lung Diseases Studies:
1. Tuberculosis Prophylaxis in the Homeless--A Controlled Trial
2. Characterizing a 5P-Linked BHR Susceptibility Locus
3. NHLBI/NICHD Collaborative Studies of Asthma in Pregnancy
4. Interventions to Improve Asthma Management/Prevention at School
5. Longitudinal Analysis of Spirometry in Black Children
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Chronic Obstructive Pulmonary Disease Gene Localization
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