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Home > "C" Clinical Trials Conditions > Chinese Exercise Modalities in Parkinson's Disease  Chinese Exercise Modalities in Parkinson's Disease
Chinese Exercise Modalities in Parkinson's Disease
For Condition: Parkinson Disease
Status: No longer recruiting
Sponsor(s): National Center for Complementary and Alternative Medicine (NCCAM) ,
Synopsis: This study will compare the effects of two Chinese and one Western exercise modalities on the signs and symptoms of Parkinson's disease.
Details: The long-term goal of this project is to study the effects of different exercise modalities on Parkinson's disease (PD). PD is a disorder whose primary disability stems from motor dysfunction including balance. Recent studies have shown that the risk of falling in the elderly can be reduced through the practice of the Chinese complementary and alternative medicine (CAM) such as T'ai Chi Chuan (TCC). This finding may be highly significant to PD. Although a recent report from Emory suggests PD patients can do well with aerobic (walk-run) exercise training (AET), it is still unclear whether the potential anti-Parkinsonian effect of such modalities is secondary to improved physical fitness (CRF), motor control or both. CAM interventions such as TCC may offer a unique opportunity to examine these fundamental questions. In PD we hypothesize that exercise training will reduce primary and secondary disability and that some of these changes represent adaptive reprogramming of central motor pathways. We will conduct a controlled double-blind, 16-week dose-response study of exercise based on caloric expenditure and thus on the cardiorespiratory fitness effects of exercise (CRF). The treatments will be Qi Gong (minimal caloric expenditure), TCC (low expenditure), and walk-cycle AET (moderate expenditure). We will examine exercise-induced change in motor control using quantitative measures of motor disability, including dynamic gait stability measures. We will also examine exercise effects on central and peripheral indices of Parkinsonian motor disability. A caloric "dose-response" effect of exercise would suggest CRF is a major determinant of the anti-Parkinsonian effects of exercise. If the Chinese modalities are as effective or superior to AET however, this would suggest that other mechanisms such as change in central motor programming may be playing a role (e.g. relaxation effects, reinforcement of central motor programs?). A better understanding of exercise-induced neural plasticity and motor control would offer a significant, and heretofore unexploited rehabilitative potential in PD.
Eligibility:
Study Type: Interventional, Treatment, Randomized
Minimum Age/Maximum Age: 40 Years/85 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Ambulatory patients with Parkinson's Disease, defined as a clinical state in which at least two of these four cardinal features are present- 1) slowness of movement, 2) tremor at rest, 3) muscular rigidity, 4) gait disturbance or posture imbalance. - Ambulatory patients with Parkinson's Disease not exercising regularly more than 2x per week. Willing to be randomly assigned to 1 of the 3 exercise modalities: Tai Chi, Qi Gong and Aerobic exercise. NOTE THAT PARTICIPATION IN THE STUDY REQUIRES BI-WEEKLY PARTICIPATION IN A 16-WEEK SUPERVISED EXERCISE PROGRAM PLUS RELATED EVALUATIONS AT EMORY. ACCORDINGLY, RECRUITMENT IS LIMITED TO LOCAL PATIENTS.
Total Enrollment: 40
Location and Contact Information:
Emory University School of Medicine
Atlanta, Georgia, 30329
United States
Additional Information:
Study ID Numbers: 1 R01 AT00612-01;
Study Start Date:
Record last reviewed: November 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00029809
Other Parkinson Disease Studies:
1. Safety and efficacy study of CEP-1347 in the treatment of Parkinson's disease
2. Phase II Double Blind Controlled Trial of Nigral Grafting in Patients With Parkinson's Disease
3. Study of Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease
4. An Open-Label, Long-Term, Flexible Dose Study of Safety, Tolerability, and Therapeutic Response In Patients with Parkinson's Disease with an Investigational Drug
5. Treatment of Agitation/Psychosis in Dementia/Parkinsonism (TAP/DAP)
Related Studies:
Other Parkinson Disease Clinical Trials
Other Georgia Clinical Trials
Other Atlanta Clinical Trials
Chinese Exercise Modalities in Parkinson's Disease
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