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Home > "C" Clinical Trials Conditions > Children's Activity and Nutrition III  Children's Activity and Nutrition III
Children's Activity and Nutrition III
For Condition: Coronary Disease,Cardiovascular Diseases,Hypertension
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To track blood pressure from childhood through adolescence.
Details: BACKGROUND: Children's Activity and Nutrition III was originally part of the Institute-initiated Studies of Children's Activity and Nutrition (SCAN), first funded in 1985. Children's Activity and Nutrition III was renewed in 1992 as a stand-alone project with a focus on assessment of the development of hemodynamic mechanisms responsible for blood pressure (BP) control within the context of ethnicity and family history of early myocardial infarction (MI), defined as having a parent or grandparent with an MI at less than 55 years of age and a family history. Blacks have a higher mortality rate through middle adulthood than whites from coronary heart disease (CHD), the leading causes of death in the United States. Blacks have been found to exhibit greater cardiovascular (CV) response to stress (i.e., reactivity), a potential risk factor for CHD, as have individuals with a family history. . Although CHD has its pathobiologic origins in childhood, little longitudinal reactivity research has been conducted in youth, especially from childhood through late adolescence. DESIGN NARRATIVE: The study follows a multiethnic sample of 250 13 to 14 year olds for an additional 5 years to determine: 1) whether blood pressure (BP) reactivity during childhood predicts changes in resting BP, left ventricular mass and concentric remodeling, carotid artery wall elasticity and endothelial dependent arterial dilation up to 11 years later after controlling for other expected predictors (i.e., age, gender, ethnicity, resting BP, adiposity, ambulatory BP); 2) the influence of ethnicity, family history and a select group of moderator variables (i.e., environmental stress, anger and John Henryism coping styles, aerobic fitness on youth's cardiovascular (CV) reactivity; and 3) the stability of CV reactivity and a 24- hour ambulatory BP from childhood through late adolescence. The long- term objectives are to provide a better understanding of the development of CV reactivity in youth and its influence upon early pathobiologic markers of coronary heart disease prior to overt manifestation of disease. This information may eventually be used to identify youth who are at greatest risk for development of coronary heart disease and foster the development of interventions that may prevent early coronary heart disease onset and improve health.
Eligibility:
Study Type: Observational, Natural History, Longitudinal, Defined Population
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: No eligibility criteria
Total Enrollment:
Location and Contact Information:
Additional Information:
Study ID Numbers: 956;
Study Start Date: April 1992
Record last reviewed: January 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00007111
Other Cardiovascular Diseases Studies:
1. Pathobiological Determinants of Atherosclerosis in Youth (PDAY)
2. Behavioral Factors in Coronary Heart Disease
3. Cardiovascular Disease Trends 1980-91--A Gender Specific Perspective
4. Logical Analysis of Data and Cardiac Surgery Risk
5. CVD Risk and Health in Postmenopausal Phytoestrogen Users
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Children's Activity and Nutrition III
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