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Home > "C" Clinical Trials Conditions > Chemotherapy, SU5416, Radiation Therapy, and Surgery in Treating Patients With Soft Tissue Sarcoma

Chemotherapy, SU5416, Radiation Therapy, and Surgery in Treating Patients With Soft Tissue Sarcoma



Chemotherapy, SU5416, Radiation Therapy, and Surgery in Treating Patients With Soft Tissue Sarcoma

For Condition: stage 3 adult soft tissue sarcoma,recurrent adult soft tissue sarcoma,stage 2C adult soft tissue sarcoma
Status: Completed
Sponsor(s): National Cancer Institute (NCI) , Radiation Therapy Oncology Group
Synopsis: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Drugs such as SU5416 may stop the growth of cancer by stopping blood flow to the tumor. Radiation therapy uses high-energy x-rays to damage tumor cells. Giving chemotherapy, SU5416, and radiation therapy before and after surgery may kill more tumor cells. PURPOSE: Phase I/II trial to study the effectiveness of chemotherapy, SU5416, radiation therapy, and surgery in treating patients who have stage IIC or stage III soft tissue sarcoma.
Details: OBJECTIVES: I. Determine the maximum tolerated dose of SU5416 when administered with neoadjuvant chemotherapy and radiotherapy and adjuvant chemotherapy in patients with high-grade stage IIC-III soft tissue sarcoma. II. Determine the disease-free survival, local control, and overall survival in patients treated with this regimen. III. Determine histological response in patients treated with this regimen. IV. Determine the toxicity of this regimen in these patients. V. Determine the quantitative antiangiogenic effects of SU5416 in patients treated with this regimen. PROTOCOL OUTLINE: This is a dose-escalation study of SU5416. Patients receive neoadjuvant chemotherapy comprising doxorubicin, ifosfamide, and dacarbazine IV continuously on days 1-3, 22-24, and 43-45. Patients also receive filgrastim (G-CSF) subcutaneously once daily beginning on day 5 and continuing until blood counts recover. Patients undergo 2 courses of radiotherapy, given once daily for 11 doses per course over days 7-20 and 28-41. Patients also receive SU5416 IV over 1 hour twice weekly beginning on day 1 and continuing until 2 days before surgery. Patients undergo surgical resection on day 80. Patients then receive adjuvant chemotherapy comprising doxorubicin, ifosfamide, and dacarbazine IV continuously on days 101-103, 122-124, and 143-145. Patients also receive SU5416 IV over 1 hour twice weekly beginning on day 101 and continuing until the end of adjuvant chemotherapy. Patients with positive surgical margins receive additional radiotherapy beginning 2 weeks after resection for a total of 8 doses. Cohorts of 3-6 patients receive escalating doses of SU5416 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter. PROJECTED ACCRUAL: Approximately 68-80 patients will be accrued for this study.
Eligibility:
Study Type:
  Interventional, Treatment
Minimum Age/Maximum Age: 18 Years/
Genders: 
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - Histologically confirmed stage IIC-III primary or locally recurrent soft tissue sarcoma; Grade 2 or 3 on grade 1-3 scale OR Grade 3 or 4 on grade 3-4 scale; Tumor size at least 8 cm in diameter - Tumor located on upper extremities (including shoulder), lower extremities (including hip), or on body wall - No rhabdomyosarcoma, extraosseous Ewing's sarcoma, primitive neuroectodermal tumors, osteosarcoma or chondrosarcoma, Kaposi's sarcoma or angiosarcoma of the scalp or face, or any sarcoma of the head and neck - No evidence of lung metastases - Maximum of 4 chest lesion no greater than 3 mm in diameter each on preoperative chest CT scans; Lesions no greater than 1 cm in diameter allowed if stable for at least 1 year and fit criteria for granulomas --Prior/Concurrent Therapy-- - Biologic therapy: No prior biologic therapy - Chemotherapy: No prior chemotherapy - Endocrine therapy: Not specified - Radiotherapy: No prior radiotherapy - Surgery: More than 2 weeks since minor surgery; More than 4 weeks since major surgery --Patient Characteristics-- - Age: 18 and over - Performance status: Zubrod 0-1 - Life expectancy: At least 2 years - Hematopoietic: WBC at least 4,000/mm3 OR Absolute neutrophil count at least 1,800/mm3; Platelet count at least 150,000/mm3; No prior bleeding or clotting diathesis - Hepatic: Bilirubin no greater than 1.5 mg/dL; AST and ALT no greater than 1.5 times upper limit of normal PT and PTT less than 1.25 times normal (not on Coumadin) - Renal: Creatinine no greater than 1.5 mg/dL OR Creatinine clearance greater than 60 mL/min - Cardiovascular: LVEF greater than 50%; History of atherosclerotic coronary artery disease (CAD) requiring bypass surgery allowed provided surgery occurred at least 1 year prior to study; No uncompensated CAD on electrocardiogram or physical examination; No myocardial infarction or severe or unstable angina within the past 6 months; No New York Heart Association class II-IV heart disease; No congestive heart failure; No severe peripheral vascular disease; No peripheral vascular disease with diabetes mellitus; No deep venous or arterial thrombosis (including pulmonary embolism) within the past 3 months - Other: Not pregnant or nursing; Negative pregnancy test; Fertile patients must use effective contraception; Fibrin split products less than 2 times normal; Fibrinogen greater than 200 mg/dL; No active uncontrolled bacterial, viral, or fungal infection; No known hypersensitivity to E. coli-derived proteins; No contraindications to limb-salvage surgery; No other prior or concurrent malignancy within the past 5 years except surgically treated carcinoma in situ of the cervix or squamous or basal cell skin cancer; No other serious medical or psychiatric illness that would preclude study
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
BurtonEisenberg,  Study Chair,  Radiation Therapy Oncology Group

Jackson-Madison County General Hospital
Jackson,  Tennessee,  38301
United States
 

Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County
Mount Holly,  New Jersey,  08060
United States
 

CCOP - Columbia River Program
Portland,  Oregon,  97213
United States
 

Greater Baltimore Medical Center and Cancer Center
Baltimore,  Maryland,  21204
United States
 

South Jersey Regional Cancer Center
Millville,  New Jersey,  08332
United States
 

Wilford Hall - 59th Medical Wing
Lackland Air Force Base,  Texas,  78236-5300
United States
 

Akron General Medical Center
Akron,  Ohio,  44302
United States
 

Radiation Oncology Associates of Albuquerque
Albuquerque,  New Mexico,  87109
United States
 

Methodist Medical Center of Illinois
Peoria,  Illinois,  61636
United States
 

Kingston Regional Cancer Centre
Kingston,  Ontario,  K7L 5P9
Canada
 

Mallinckrodt Institute of Radiology
St. Louis,  Missouri,  63108
United States
 

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore,  Maryland,  21231-2410
United States
 

St. Luke's Medical Center
Milwaukee,  Wisconsin,  53215
United States
 

MD Anderson Cancer Center Orlando
Orlando,  Florida,  32806
United States
 

CCOP - Cancer Research for the Ozarks
Springfield,  Missouri,  65807
United States
 

Nebraska Health System
Omaha,  Nebraska,  68198-7460
United States
 

Community Memorial Hospital
Menomonee Falls,  Wisconsin,  53051
United States
 

Anne Arundel Oncology Center
Annapolis,  Maryland,  21401
United States
 

CCOP - Kansas City
Kansas City,  Missouri,  64131
United States
 

Ball Memorial Hospital
Muncie,  Indiana,  47303-3499
United States
 

Allan Blair Cancer Centre
Regina,  Saskatchewan,  S4T 7T1
Canada
 

CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
Syracuse,  New York,  13217
United States
 

McGill University
Montreal,  Quebec,  H2W 1S6
Canada
 

Harrington Cancer Center
Amarillo,  Texas,  79106
United States
 

Loma Linda University Medical Center
Loma Linda,  California,  92354
United States
 

Merle M. Mahr Cancer Center
Madisonville,  Kentucky,  42431
United States
 

CCOP - Greenville
Greenville,  South Carolina,  29615
United States
 

Saskatoon Cancer Centre
Saskatoon,  Saskatchewan,  S7N 4H4
Canada
 

Florida Radiation Oncology Group
Orange Park,  Florida,  32073
United States
 

Vanderbilt-Ingram Cancer Center
Nashville,  Tennessee,  37232-6838
United States
 

Veterans Affairs Medical Center - Long Beach
Long Beach,  California,  90822
United States
 

Fitzgerald Mercy Hospital
Darby,  Pennsylvania,  19023
United States
 

Ottawa Regional Cancer Centre
Ottawa,  Ontario,  K1H 1C4
Canada
 

Medical Center/John B. Amos Community Cancer Center
Columbus,  Georgia,  31902
United States
 

Cleveland Clinic Taussig Cancer Center
Cleveland,  Ohio,  44195
United States
 

Mary Bird Perkins Cancer Center
Baton Rouge,  Louisiana,  70809
United States
 

East Carolina University School of Medicine
Greenville,  North Carolina,  27858-4354
United States
 

Cape Cod Hospital
Hyannis,  Massachusetts,  02601
United States
 

CCOP - Columbus
Columbus,  Ohio,  43206
United States
 

Foundation for Cancer Research and Education
Phoenix,  Arizona,  85013
United States
 

Valley Hospital
Ridgewood,  New Jersey,  07450
United States
 

Cancer Center and Beckman Research Institute, City of Hope
Duarte,  California,  91010-3000
United States
 

Cancer Institute of New Jersey
New Brunswick,  New Jersey,  08903
United States
 

Albert B. Chandler Medical Center, University of Kentucky
Lexington,  Kentucky,  40536-0084
United States
 

Arthur G. James Cancer Hospital - Ohio State University
Columbus,  Ohio,  43210-1240
United States
 

Virginia Mason Medical Center
Seattle,  Washington,  98111
United States
 

Cancer Center at the University of Virginia
Charlottesville,  Virginia,  22908
United States
 

Alabama Oncology, LLC
Montgomery,  Alabama,  36106-2801
United States
 

Herbert Irving Comprehensive Cancer Center
New York City,  New York,  10032
United States
 

Harbor Hospital Center
Baltimore,  Maryland,  21225
United States
 

University of Pennsylvania Cancer Center
Philadelphia,  Pennsylvania,  19104-4283
United States
 

CCOP - Ann Arbor Regional
Ann Arbor,  Michigan,  48106
United States
 

Champlain Valley Physicians Hospital Medical Center
Plattsburgh,  New York,  12901
United States
 

Sutter Health West Cancer Research Group
Greenbrae,  California,  94904
United States
 

New York Methodist Hospital
Brooklyn,  New York,  11215-3609
United States
 

Health First Holmes Regional Medical Center
Melbourne,  Florida,  32901
United States
 

Community Medical Center
Toms River,  New Jersey,  08755
United States
 

Deaconess Medical Center
Spokane,  Washington,  99210-0248
United States
 

Trinity Cancer Care Center
Minot,  North Dakota,  58701
United States
 

Baptist Hospital of Miami
Miami,  Florida,  33176-2197
United States
 

Centre Hospitalier Universitaire de Quebec
Quebec City,  Quebec,  G1R 2J6
Canada
 

O'Connor Hospital
San Jose,  California,  95128
United States
 

UCSF Cancer Center and Cancer Research Institute
San Francisco,  California,  94143-0128
United States
 

CCOP - Upstate Carolina
Spartanburg,  South Carolina,  29303
United States
 

Peninsula Regional Medical Center
Salisbury,  Maryland,  21801
United States
 

Wendt Regional Cancer Center of Finley Hospital
Dubuque,  Iowa,  52001
United States
 

CCOP - Montana Cancer Consortium
Billings,  Montana,  59101
United States
 

Akron City Hospital
Akron,  Ohio,  44309
United States
 

Lutheran General Cancer Care Center
Park Ridge,  Illinois,  60068
United States
 

Nova Scotia Cancer Centre
Halifax,  Nova Scotia,  B3H 1V7
Canada
 

Marquette General Hospital
Marquette,  Michigan,  49855
United States
 

CCOP - Central Illinois
Decatur,  Illinois,  62526
United States
 

Cancer Research for the Ozarks
Springfield,  Missouri,  65807
United States
 

H. Lee Moffitt Cancer Center and Research Institute
Tampa,  Florida,  33612-9497
United States
 

University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham,  Alabama,  35294-3300
United States
 

Saint Mary's Hospital and Medical Center
Grand Junction,  Colorado,  81502
United States
 

Gundersen Lutheran Medical Foundation
La Crosse,  Wisconsin,  54601
United States
 

University of Rochester Cancer Center
Rochester,  New York,  14642
United States
 

St. John Health System
Tulsa,  Oklahoma,  74104
United States
 

Milton S. Hershey Medical Center
Hershey,  Pennsylvania,  17033-0850
United States
 

Southeastern Wisconsin Regional Cancer Center
Racine,  Wisconsin,  53405
United States
 

Northwestern Ontario Regional Cancer Centre, Thunder Bay
Thunder Bay,  Ontario,  P7A 7T1
Canada
 

McLaren Regional Cancer Center
Flint,  Michigan,  48432
United States
 

Veterans Affairs Medical Center - Miami
Miami,  Florida,  33125
United States
 

Clarian Health Partners Inc.
Indianapolis,  Indiana,  46206-1367
United States
 

Schiffler Cancer Center
Wheeling,  West Virginia,  26003
United States
 

University of Wisconsin Comprehensive Cancer Center
Madison,  Wisconsin,  53792-6164
United States
 

University of Colorado Cancer Center
Denver,  Colorado,  80010
United States
 

CCOP - Southern Nevada Cancer Research Foundation
Las Vegas,  Nevada,  89106
United States
 

Ireland Cancer Center
Cleveland,  Ohio,  44106-5065
United States
 

Naval Medical Center, Portsmouth
Portsmouth,  Virginia,  23708-2197
United States
 

CCOP - Kalamazoo
Kalamazoo,  Michigan,  49007-3731
United States
 

Yakima Valley Memorial Hospital
Yakima,  Washington,  98902
United States
 

MBCCOP - LSU Health Sciences Center
New Orleans,  Louisiana,  70112
United States
 

William Beaumont Hospital - Troy
Troy,  Michigan,  48098
United States
 

William Beaumont Hospital
Royal Oak,  Michigan,  48073
United States
 

Radiation Medical Group, Inc.
San Diego,  California,  92101-1492
United States
 

Northeast Medical Center
Concord,  North Carolina,  28025
United States
 

University Hospitals of Cleveland
Cleveland,  Ohio,  44106
United States
 

Princess Margaret Hospital
Toronto,  Ontario,  M5G 2M9
Canada
 

Centre Hospitalier de l'Universite de Montreal
Montreal,  Quebec,  H2L-4M1
Canada
 

University of Tennessee, Memphis Cancer Center
Memphis,  Tennessee,  38103
United States
 

Cancer Center of Albany Medical Center
Albany,  New York,  12208
United States
 

MBCCOP - Gulf Coast
Mobile,  Alabama,  36688
United States
 

Southern Wisconsin Radiotherapy Center
Madison,  Wisconsin,  53713
United States
 

John F. Kennedy Medical Center
Edison,  New Jersey,  08818
United States
 

University of Pittsburgh Cancer Institute
Pittsburgh,  Pennsylvania,  15213-3489
United States
 

Massey Cancer Center
Richmond,  Virginia,  23298-0037
United States
 

CCOP - Northern Indiana CR Consortium
South Bend,  Indiana,  46601
United States
 

Massachusetts General Hospital Cancer Center
Boston,  Massachusetts,  02114
United States
 

Cancer Care Center
Pomona,  California,  91767
United States
 

Western Pennsylvania Hospital
Pittsburgh,  Pennsylvania,  15224
United States
 

St. Vincent Hospital
Green Bay,  Wisconsin,  54307-3508
United States
 

Toronto Sunnybrook Regional Cancer Centre
Toronto,  Ontario,  M4N 3M5
Canada
 

Huntsville Hospital System
Huntsville,  Alabama,  35801-4470
United States
 

Radiation Oncology Center - Sacramento
Sacramento,  California,  95816
United States
 

MidMichigan Medical Center - Midland
Midland,  Michigan,  48670
United States
 

Medical College of Wisconsin
Milwaukee,  Wisconsin,  53226
United States
 

Bon-Secours - St. Mary's Hospital
Richmond,  Virginia,  23226
United States
 

Associated Radiologists, P.A.
Warren,  New Jersey,  07059
United States
 

CCOP - Christiana Care Health Services
Wilmington,  Delaware,  19899
United States
 

Northeastern Ontario Regional Cancer Centre, Sudbury
Sudbury,  Ontario,  P3E 5J1
Canada
 

Memorial Hospital Cancer Center
Colorado Springs,  Colorado,  80909
United States
 

Emory University Hospital - Atlanta
Atlanta,  Georgia,  30322
United States
 

University of Texas Medical Branch
Galveston,  Texas,  77555-0209
United States
 

Cross Cancer Institute
Edmonton,  Alberta,  T6G 1Z2
Canada
 

Loyola University Medical Center
Maywood,  Illinois,  60153
United States
 

Community Hospitals of Indianapolis - Regional Cancer Center
Indianapolis,  Indiana,  46219
United States
 

RMH Regional Cancer Center
Harrisonburg,  Virginia,  22801
United States
 

Lehigh Valley Hospital
Allentown,  Pennsylvania,  18103
United States
 

Regional Radiation Oncology Center at Rome
Rome,  Georgia,  30165
United States
 

Lineberger Comprehensive Cancer Center, UNC
Chapel Hill,  North Carolina,  27599-7295
United States
 

Sylvester Cancer Center, University of Miami
Miami,  Florida,  33136
United States
 

Northwest Community Hospital
Arlington Heights,  Illinois,  60005
United States
 

Veterans Affairs Medical Center - Boston (Jamaica Plain)
Jamaica Plain,  Massachusetts,  02130
United States
 

CCOP - Dayton
Kettering,  Ohio,  45429
United States
 

Louisville Radiation Oncology
Louisville,  Kentucky,  40215
United States
 

Huntington Cancer Center
Pasadena,  California,  91105
United States
 

University of Florida Health Science Center
Gainesville,  Florida,  32610-0296
United States
 

St. Francis Medical Center
Trenton,  New Jersey,  08629
United States
 

State University of New York Health Science Center at Brooklyn
Brooklyn,  New York,  11203
United States
 

Riverhill Radiation Oncology
Yonkers,  New York,  10701
United States
 

Newfoundland Cancer Treatment and Research Foundation
St. Johns,  Newfoundland and Labrador,  A1B 3V6
Canada
 

St. Louis University Health Sciences Center
St. Louis,  Missouri,  63110-0250
United States
 

Tom Baker Cancer Center - Calgary
Calgary,  Alberta,  T2N 4N2
Canada
 

CCOP - North Shore University Hospital
Manhasset,  New York,  11030
United States
 

York Hospital
York,  Pennsylvania,  17315
United States
 

Barbara Ann Karmanos Cancer Institute
Detroit,  Michigan,  48201-1379
United States
 

Bloomington Hospital
Bloomington,  Indiana,  47402
United States
 

Roswell Park Cancer Institute
Buffalo,  New York,  14263-0001
United States
 

Monmouth Medical Center
Long Branch,  New Jersey,  07740-6395
United States
 

CCOP - Southeast Cancer Control Consortium
Winston Salem,  North Carolina,  27104-4241
United States
 

Finger Lakes Radiation Oncology Center
Clifton Springs,  New York,  14432
United States
 

Central Baptist Hospital
Lexington,  Kentucky,  40503
United States
 

Mount Diablo Medical Center
Concord,  California,  94524-4110
United States
 

Sarasota Radiation and Medical Oncology Center
Sarasota,  Florida,  34233
United States
 

Latter Day Saints Hospital
Salt Lake City,  Utah,  84143
United States
 

Geisinger Medical Center
Danville,  Pennsylvania,  17822-2001
United States
 

Ingalls Memorial Hospital
Harvey,  Illinois,  60426
United States
 

Veterans Affairs Medical Center - Indianapolis (Roudebush)
Indianapolis,  Indiana,  46202
United States
 

University of Utah Health Sciences Center
Salt Lake City,  Utah,  84132
United States
 

CCOP - Metro-Minnesota
St. Louis Park,  Minnesota,  55416
United States
 

Henry Ford Hospital
Detroit,  Michigan,  48202
United States
 

USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles,  California,  90033-0804
United States
 

Mercy Hospital of Pittsburgh
Pittsburgh,  Pennsylvania,  15219
United States
 

James Graham Brown Cancer Center
Louisville,  Kentucky,  40202
United States
 

Comprehensive Cancer Center at Wake Forest University
Winston Salem,  North Carolina,  27157-1082
United States
 

St. John's Medical Center
Anderson,  Indiana,  46016
United States
 

Hurley Medical Center
Flint,  Michigan,  48503
United States
 

Ellis Fischel Cancer Center - Columbia
Columbia,  Missouri,  65203
United States
 

Tulane University School of Medicine
New Orleans,  Louisiana,  70112
United States
 

Reading Hospital and Medical Center
Reading,  Pennsylvania,  19612-6052
United States
 

Dixie Regional Medical Center
St. George,  Utah,  84770
United States
 

CCOP - Mount Sinai Medical Center
Miami,  Florida,  33140
United States
 

Sinai Hospital of Baltimore
Baltimore,  Maryland,  21225
United States
 

Vassar Brothers Hospital
Poughkeepsie,  New York,  12601
United States
 

St. Anthony Hospital
Oklahoma City,  Oklahoma,  73101
United States
 

Northwestern Memorial Hospital
Chicago,  Illinois,  60611
United States
 

CHUS-Hopital Fleurimont
Fleurimont,  Quebec,  J1H 5N4
Canada
 

CCOP - Santa Rosa Memorial Hospital
Santa Rosa,  California,  95403
United States
 

Veterans Affairs Medical Center - Philadelphia
Philadelphia,  Pennsylvania,  19104
United States
 

Columbia Hospital
Milwaukee,  Wisconsin,  53211
United States
 

Albert Einstein Cancer Center
Philadelphia,  Pennsylvania,  19141
United States
 

Fox Chase Cancer Center
Philadelphia,  Pennsylvania,  19111
United States
 

Christ Hospital
Cincinnati,  Ohio,  45219
United States
 

Saint John Regional Hospital
Saint John,  New Brunswick,  E2L 4L2
Canada
 

Veterans Affairs Medical Center - East Orange
East Orange,  New Jersey,  07018-1095
United States
 

Waukesha Memorial Hospital
Waukesha,  Wisconsin,  53188
United States
 

Comprehensive Cancer Institute of Huntsville
Huntsville,  Alabama,  35801
United States
 

Newark Beth Israel Medical Center
Newark,  New Jersey,  07112
United States
 

Mercy Hospital Cancer Center - Scranton
Scranton,  Pennsylvania,  18501
United States
 

CCOP - Bay Area Tumor Institute
Oakland,  California,  94609-3305
United States
 

David Grant Medical Center
Travis Air Force Base,  California,  94535
United States
 

Bay Medical Center
Panama City,  Florida,  32401
United States
 

MBCCOP - Hawaii
Honolulu,  Hawaii,  96813
United States
 

Saint Agnes Cancer Center
Fresno,  California,  93720
United States
 

Maine Medical Center
Portland,  Maine,  04102
United States
 

University of Michigan Comprehensive Cancer Center
Ann Arbor,  Michigan,  48109-0752
United States
 

Barrett Cancer Center, The University Hospital
Cincinnati,  Ohio,  45267-0502
United States
 

University of Oklahoma Health Sciences Center
Oklahoma City,  Oklahoma,  73190
United States
 

Methodist Cancer Center - Omaha
Omaha,  Nebraska,  68114
United States
 

Radiation Oncology Associates of West Alabama
Tuscallosa,  Alabama,  35401
United States
 

Norris Cotton Cancer Center
Lebanon,  New Hampshire,  03756-0002
United States
 

Cancer Care Ontario-London Regional Cancer Centre
London,  Ontario,  N6A 4L6
Canada
 

Jonsson Comprehensive Cancer Center, UCLA
Los Angeles,  California,  90095-1781
United States
 

Gulf Coast Cancer Treatment Center
Panama City,  Florida,  32405-4587
United States
 

Tallahassee Memorial Healthcare
Tallahassee,  Florida,  32308
United States
 

St. Luke's Hospital Regional Cancer Center
Bethlehem,  Pennsylvania,  18015
United States
 

Marshfield Clinic
Marshfield,  Wisconsin,  54449
United States
 

University of Texas - MD Anderson Cancer Center
Houston,  Texas,  77030-4009
United States
 

Atlantic City Medical Center
Pomona,  New Jersey,  08240
United States
 

Joe Arrington Cancer Research and Treatment Center
Lubbock,  Texas,  79410-1894
United States
 

CCOP - Atlanta Regional
Atlanta,  Georgia,  30342-1701
United States
 

Cancer Care Ontario-Hamilton Regional Cancer Centre
Hamilton,  Ontario,  L8V 5C2
Canada
 

Delaware County Memorial Hospital
Drexel Hill,  Pennsylvania,  19026
United States
 

Pocono Cancer Center
East Stroudsburg,  Pennsylvania,  18301
United States
 

CCOP - Ochsner
New Orleans,  Louisiana,  70121
United States
 

Trinitas Hospital - Jersey Street Campus
Elizabeth,  New Jersey,  07201
United States
 

Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
Philadelphia,  Pennsylvania,  19107-5541
United States
 

Vermont Cancer Center
Burlington,  Vermont,  05401-3498
United States
 

CCOP - Toledo Community Hospital Oncology Program
Toledo,  Ohio,  43623-3456
United States
 

Roger Williams Medical Center/BUSM
Providence,  Rhode Island,  02908-4735
United States
 

California Cancer Center
Fresno,  California,  93720
United States
 

Mayo Clinic Cancer Center
Rochester,  Minnesota,  55905
United States
 

Elliot Regional Cancer Center
Manchester,  New Hampshire,  03103
United States
 

Wilkes Barre General Hospital
Wilkes Barre,  Pennsylvania,  18764
United States
 


Additional Information:
Study ID Numbers:
  CDR0000068855;  RTOG-S-0121
Study Start Date: 
Record last reviewed: October 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00023738

Other Stage 3 Adult Soft Tissue Sarcoma Studies:
1. Combination Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Primary or Recurrent Sarcoma

2. Interferon alfa and Thalidomide in Treating Patients With Soft Tissue Sarcoma or Bone Sarcoma

3. Radiation Therapy Plus Doxorubicin in Treating Patients With Resectable Primary or Recurrent Retroperitoneal Soft Tissue Sarcoma

4. Chemotherapy, SU5416, Radiation Therapy, and Surgery in Treating Patients With Soft Tissue Sarcoma

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Other stage 3 adult soft tissue sarcoma Clinical Trials
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Chemotherapy, SU5416, Radiation Therapy, and Surgery in Treating Patients With Soft Tissue Sarcoma

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