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Chemotherapy in Treating Children With Liver Cancer Clinical Trials Information presented on Clinical Trials Search is not designed to be a substitute for proven healthcare advice, travels to or treatment by using a genuine medical doctor. We are not physicians. Always confer with your doctor on Chemotherapy in Treating Children With Liver Cancer conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Chemotherapy in Treating Children With Liver Cancer Clinical research trials and Chemotherapy in Treating Children With Liver Cancer healthcare trials take place in many of cities across the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectiveness of new drugs. The function of the studies / undertakings is to answer specific human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector companies to find treatments for all forms of conditions, including Chemotherapy in Treating Children With Liver Cancer. Chemotherapy in Treating Children With Liver Cancer Clinical Trials and other clinical trials allow for volunteers to access medical treatment alternatives before they are available to the masses. Many times the test subjects undergo treatment for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a Chemotherapy in Treating Children With Liver Cancer clinical trial. Test subjects oftentimes recieve the best healthcare possible for their Chemotherapy in Treating Children With Liver Cancer condition. Hazards are a reality, nonetheless, and might include additional or frequent doctor trips, healthcare hazards (perhaps life-jeopardizing), and/or the treatment being ineffective. Trials are federally regulated with rigid guidelines to protect clinical trials subjects.
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Home > "C" Clinical Trials Conditions > Chemotherapy in Treating Children With Liver Cancer  Chemotherapy in Treating Children With Liver Cancer
Chemotherapy in Treating Children With Liver Cancer
For Condition: childhood liver cancer,childhood hepatoblastoma,childhood hepatocellular carcinoma
Status: Recruiting
Sponsor(s): Societe Internationale d'Oncologie Pediatrique ,
Synopsis: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which chemotherapy regimen is more effective in treating children with liver cancer. PURPOSE: Randomizedphase III trial to study the effectiveness of cisplatin with or without doxorubicin and the effectiveness of combining cisplatin, carboplatin, and doxorubicin in treating children who have liver cancer.
Details: OBJECTIVES: - Compare the efficacy of cisplatin with or without doxorubicin in terms of tumor response, complete resection rate, overall survival, and event free survival in children with standard risk hepatoblastoma. - Compare the toxicity of cisplatin with or without doxorubicin in this patient population. - Evaluate whether an intensive multiagent regimen including carboplatin, cisplatin, and doxorubicin improves the response rate to chemotherapy and subsequent resection rate of children with high risk hepatoblastoma or hepatocellular carcinoma. OUTLINE: This is a randomized, multicenter study. All hepatoblastoma patients are intended to be treated with primary chemotherapy. Hepatoblastoma patients are stratified by risk (standard vs high). Patients receive cisplatin IV over 24 hours on day 1, beginning within 15 days of diagnosis. Standard risk patients are then randomized to one of two treatment arms. High risk hepatoblastoma patients and hepatocellular carcinoma patients receive a separate multiagent regimen. - Arm I: Patients receive cisplatin IV over 24 hours and doxorubicin IV over 48 hours beginning on day 15. Treatment repeats every 21 days for a maximum of 5 courses. Tumor response is evaluated prior to the second course. Patients with responsive disease receive the remaining 2 courses of the preoperative phase, then undergo delayed primary surgery if their tumors are deemed resectable, prior to receiving 2 additional courses of chemotherapy. Patients whose tumors are still unresectable after 3 courses receive 2 more courses of chemotherapy, then undergo surgery if feasible. Patients with stable disease are considered for radical surgery or salvage chemotherapy. Patients with unresectable tumors after 5 courses may be considered for liver transplant or salvage chemotherapy. - Arm II: Patients receive cisplatin IV over 24 hours every 15 days for a maximum of 5 additional courses. Tumor response is evaluated after the second course. Patients with responsive disease receive another 2 courses of cisplatin. Patients with resectable tumors after 4 courses undergo delayed primary surgery, then receive 2 more courses of cisplatin. Patients whose tumors are still unresectable after 4 courses receive 2 more courses of cisplatin, then undergo surgery if their tumors are resectable. Patients with stable disease may be moved to the high risk regimen or considered for radical surgery. Patients with unresectable tumors after 6 courses may be considered for liver transplant or salvage chemotherapy. Patients with high risk hepatoblastoma or unresectable hepatocellular carcinoma receive cisplatin IV over 24 hours on days 29, 57, and 85, and carboplatin IV over 1 hour followed by doxorubicin IV over 48 hours on days 15, 43, and 71. Patients with responsive resectable disease undergo surgery either after day 43 or within 3 weeks of day 85 of preoperative chemotherapy, then receive another 2 courses of carboplatin and doxorubicin on days 1 and 29 post surgery, and one more course of cisplatin on day 15 post surgery, for a total of 5 courses each. Patients with responsive but unresectable disease after day 85 also receive 2 more courses of carboplatin and doxorubicin alternating with 1 course of cisplatin. Definitive surgery will be re-considered after these further courses of chemotherapy. Patients with stable disease at day 43 or a tumor that remains unresectable after completion of chemotherapy may be considered for liver transplant. Patients with a resectable hepatocellular carcinoma have primary surgery followed by alternating courses of cisplatin, and carboplatin and doxorubicin for a total of 4 courses of cisplatin and 3 courses of carboplatin and doxorubicin. Patients are followed every 2-3 months for 2 years, every 6 months for 1 year, then annually thereafter. PROJECTED ACCRUAL: A total of 170-260 patients (85-130 patients per treatment arm) will be accrued for this study over 5.5 years.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: /16 Years
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically proven hepatoblastoma or hepatocellular carcinoma - Diagnostic surgical biopsy strongly recommended for all patients and mandatory for the following: - Children under 6 months of age - Children over 3 years of age - Patients with a normal serum alfa-fetoprotein (alfa-FP) - Compatible imaging and raised serum alfa-FP level mandatory if no biopsy performed - Standard risk disease: - Tumors involving no more than 3 hepatic sections - No extrahepatic abdominal disease - No metastases - High risk disease: - Tumors involving all 4 hepatic sections AND/OR - Evidence of extrahepatic metastases or abdominal disease - Presence or absence of metastatic disease must be documented by chest x-ray and/or lung CT scan PATIENT CHARACTERISTICS: Age: - 16 and under at diagnosis Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Not specified Renal: - Not specified PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - Not specified Endocrine therapy: - Not specified Radiotherapy: - Not specified Surgery: - See Disease Characteristics - Prior surgery allowed
Total Enrollment:
Location and Contact Information:
Overall Study Official:
GiorgioPerilongo, Study Chair, University of Padua
University of Padua *Recruiting*
Padua, , 35128
Italy
Recruiting Giorgio Perilongo 39-049-821-3517
Additional Information:
Study ID Numbers: CDR0000067091; SIOP-SIOPEL-3,EU-98067
Study Start Date:
Record last reviewed: December 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00003912
Other Childhood Hepatocellular Carcinoma Studies:
1. Chemotherapy in Treating Children With Liver Cancer
Related Studies:
Other childhood hepatocellular carcinoma Clinical Trials
Other Clinical Trials
Other Padua Clinical Trials
Chemotherapy in Treating Children With Liver Cancer
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