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Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified health advice, travels to or treatment by using a genuine physician. We are not physicians. Always consult your dr. on Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer conditions. Clinical Trials Search.org is a site committed to listing clinical research studies in human subjects. Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer Clinical research trials and Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer health trials occur in hundreds of cities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectivity of new drugs. The propose of the studies / undertakings is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector companies to locate treatments for all sorts of conditions, including Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer. Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer Clinical Trials and other clinical trials permit volunteers to acquire medical treatment choices before they are available to the masses. Some times the test subjects obtain professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer clinical trial. Participants oftentimes recieve the most expert healthcare available for their Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer condition. Hazards are a reality, however, and can include extra or frequent physician visits, health risks (potentially life-endangering), and/or the treatment being uneffective. Trials are federally governed with rigorous guidelines to protect clinical trials subjects.
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Home > "C" Clinical Trials Conditions > Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer  Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer
Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer
For Condition: adenocarcinoma of the stomach,stage 3 gastric cancer,stage 2 gastric cancer,stage 4 gastric cancer,stage 1 gastric cancer
Status: No longer recruiting
Sponsor(s): Radiation Therapy Oncology Group , National Cancer Institute (NCI)
Synopsis: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of chemotherapy and radiation therapy in treating patients who have stomach cancer.
Details: OBJECTIVES: - Determine the feasibility of preoperative chemoradiotherapy in patients with potentially resectable adenocarcinoma of the stomach. - Determine the pathologic response rate, curative resection rate, and survival in patients treated with this regimen. - Determine the tolerability of this regimen in these patients. OUTLINE: Patients receive fluorouracil IV over 24 hours on days 1-21, cisplatin IV over 1 hour on days 1-5, and leucovorin calcium IV over 15 minutes on days 1, 7, 14, and 21. A second course is administered beginning on day 29. Chemoradiotherapy begins between 4 and 6 weeks after the beginning of the last course of chemotherapy. Patients receive fluorouracil IV over 24 hours 5 days a week concurrently with radiotherapy for 5 weeks and paclitaxel IV over 3 hours once weekly during these 5 weeks on days 1, 8, 15, 22, and 29. Approximately 4-5 weeks after chemoradiotherapy, patients with no evidence of metastatic disease undergo surgical resection. Patients are followed every 3 months for 1 year, every 6 months for 5 years, then annually thereafter. PROJECTED ACCRUAL: A total of 21-49 patients will be accrued for this study within 2.5 years.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically proven adenocarcinoma of the stomach - Stage IB, II, IIIA, IIIB, and IV (T2-3, any N, M0) - No lymph node metastases outside the field of resection (e.g., supraclavicular, mediastinal, or paraaortic nodes) - Potentially resectable - May involve the gastroesophageal junction, but bulk of tumor must be in the stomach - No distant metastases - No pleural or pericardial effusion - No peritoneal disease diagnosed by laparoscopy PATIENT CHARACTERISTICS: Age: - Not specified Performance status: - Zubrod 0-2 Life expectancy: - At least 16 weeks Hematopoietic: - Absolute granulocyte count greater than 2,000/mm^3 - Platelet count greater than 100,000/mm^3 Hepatic: - Bilirubin no greater than 1.5 mg/dL Renal: - Creatinine less than 1.5 mg/dL Cardiovascular: - No New York Heart Association class III or IV heart disease - No hypertension Neurologic: - No cerebrovascular disease - No diabetic neuropathy - No mental status abnormalities Other: - No uncontrolled diabetes - No infection - No other malignancies within past 5 years except resected squamous cell or basal cell skin cancer - Not pregnant or nursing - Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: - No prior immunotherapy Chemotherapy: - No prior chemotherapy Endocrine therapy: - Not specified Radiotherapy: - No prior radiotherapy to stomach Surgery: - No prior surgery to stomach
Total Enrollment:
Location and Contact Information:
Overall Study Official:
JafferAjani, Study Chair, M.D. Anderson Cancer Center
McLaren Regional Cancer Center
Flint, Michigan, 48532-3685
United States
Ireland Cancer Center
Cleveland, Ohio, 44106-5065
United States
Northridge Hospital Medical Center
Northridge, California, 91328
United States
Penrose - St. Francis Health Services
Colorado Springs, Colorado, 80933
United States
Lankenau Cancer Center at Lankenau Hospital
Wynnewood, Pennsylvania, 19096
United States
Rapid City Regional Hospital
Rapid City, South Dakota, 57709
United States
Albert Einstein Cancer Center
Philadelphia, Pennsylvania, 19141-3098
United States
University of Washington Medical Center
Seattle, Washington, 98195-6043
United States
Ball Memorial Hospital Cancer Center
Muncie, Indiana, 47303-3499
United States
Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina
Greenville, North Carolina, 27835-6028
United States
Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha
Omaha, Nebraska, 68114-4199
United States
Ellis Fischel Cancer Center at University of Missouri - Columbia
Columbia, Missouri, 65203
United States
University of California Davis Cancer Center
Sacramento, California, 95817
United States
Indiana University Cancer Center
Indianapolis, Indiana, 46202-5289
United States
St. Joseph Hospital
Denver, Colorado, 80218-1191
United States
University of Texas - MD Anderson Cancer Center
Houston, Texas, 77030-4009
United States
St. Luke's Hospital Cancer Center
Bethlehem, Pennsylvania, 18015
United States
Mount Diablo Medical Center
Concord, California, 94524-4110
United States
Rose Medical Center
Denver, Colorado, 80220
United States
CCOP - Atlanta Regional
Atlanta, Georgia, 30342-1701
United States
Columbia Hospital
Milwaukee, Wisconsin, 53211
United States
Paoli Memorial Hospital
Paoli, Pennsylvania, 19301-1792
United States
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania, 19010
United States
Providence Alaska Medical Center
Anchorage, Alaska, 99519-6604
United States
Mercy Fitzgerald Hospital
Darby, Pennsylvania, 19023
United States
CCOP - MainLine Health
Wynnewood, Pennsylvania, 19096
United States
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
Grand Junction, Colorado, 81502-1628
United States
Veterans Affairs Medical Center - Indianapolis (Roudebush)
Indianapolis, Indiana, 46202
United States
Delaware County Memorial Hospital
Drexel Hill, Pennsylvania, 19026
United States
Harrington Cancer Center
Amarillo, Texas, 79106
United States
Fox Chase Cancer Center at St. Francis Medical Center
Trenton, New Jersey, 08629
United States
Porter Memorial Hospital
Valparaiso, Indiana, 46383
United States
LDS Hospital
Salt Lake City, Utah, 84143
United States
CCOP - Upstate Carolina
Spartanburg, South Carolina, 29303
United States
Presbyterian Hospital
Charlotte, North Carolina, 28233-3549
United States
CCOP - Colorado Cancer Research Program, Incorporated
Denver, Colorado, 80224
United States
Foundation for Cancer Research and Education
Phoenix, Arizona, 85013
United States
Wayne Memorial Hospital, Inc.
Goldsboro, North Carolina, 27533
United States
Norris Cotton Cancer Center at Dartmouth Medical School
Lebanon, New Hampshire, 03756-0002
United States
McKay-Dee Hospital Center
Ogden, Utah, 84403
United States
Lutheran General Hospital Cancer Care Center
Park Ridge, Illinois, 60068
United States
CCOP - Marshfield Clinic Research Foundation
Marshfield, Wisconsin, 54449
United States
Utah Valley Regional Medical Center - Provo
Provo, Utah, 84604
United States
Presbyterian-St Luke's Medical Center
Denver, Colorado, 80218
United States
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital
Mount Holly, New Jersey, 08060
United States
CCOP - Kansas City
Kansas City, Missouri, 64131
United States
Swedish Medical Center
Englewood, Colorado, 80110
United States
Western Pennsylvania Hospital
Pittsburgh, Pennsylvania, 15224
United States
CCOP - Greenville
Greenville, South Carolina, 29615
United States
CCOP - Dayton
Dayton, Ohio, 45429
United States
Monmouth Medical Center
Long Branch, New Jersey, 07740-6395
United States
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
Syracuse, New York, 13217
United States
CCOP - Toledo Community Hospital
Toledo, Ohio, 43623-3456
United States
Wendt Regional Cancer Center of Finley Hospital
Dubuque, Iowa, 52001
United States
Greenville Hospital System
Greenville, South Carolina, 29605
United States
Additional Information:
Study ID Numbers: CDR0000067026; RTOG-9904,RTOG-DEV-1046
Study Start Date:
Record last reviewed: May 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00003862
Other Stage 3 Gastric Cancer Studies:
1. Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer
2. Surgery With or Without Combination Chemotherapy in Treating Patients With Stomach Cancer
3. Oxaliplatin and Fluorouracil Plus Radiation Therapy in Treating Patients With Primary Esophageal or Stomach Cancer
4. Biological Therapy in Treating Patients With Advanced Cancer
5. Antineoplaston Therapy in Treating Patients With Stomach Cancer
Related Studies:
Other stage 3 gastric cancer Clinical Trials
Other Texas Clinical Trials
Other Amarillo Clinical Trials
Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer
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