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Chemoprevention with Folic Acid



Chemoprevention with Folic Acid

For Condition: Colon Cancer,Adenoma,Colonic Polyps
Status: Recruiting
Sponsor(s): Department of Veterans Affairs Medical Research Service ,
Synopsis: Colorectal neoplasia is the second most common cancer in the United States and other Western countries with about 140,000 newly diagnosed cases per year in the United States with a mortality rate of about 40%. The identification of a specific natural or synthetic compound with the ability to reverse or suppress the process of colon carcinogenesis would have profound implication in the development of colorectal adenomas and their subsequent transformation to colon cancer. Furthermore, the establishment of a correlative relationship between biomarkers of cell proliferation, differentiation, apoptosis and adenoma recurrence would provide pivotal data required to elucidate cell signaling mechanisms in future colon cancer chemoprevention trials.
Details:
Eligibility:
Study Type:
  Interventional, Prevention, Randomized, Double-Blind, Placebo Control, Efficacy Study
Minimum Age/Maximum Age: 18 Years/80 Years
Genders: Both
Protocol Entry Criteria: Asymptomatic individuals from the age of 18 -80 years, undergoing clinically indicated colonoscopy for colon polyps noted on screening flexible sigmoidoscopy or as routine surveillance for a history of colon polyps, who are found to have at least one adenoma > 0.5cm will be eligible for entry.
Total Enrollment: 

Location and Contact Information:

Department of Veterans Affairs *Recruiting*
Detroit,  Michigan,  48201
United States
Recruiting Majumdar  Adhip 313-576-4460


Additional Information:
Study ID Numbers:
  ONCO-021-98S; 
Study Start Date: October 1998
Record last reviewed: June 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00018551

Other Adenoma Studies:
1. Rectal Aberrant Crypt Foci and Other Intermediate Biomarkers for Sporadic Colorectal Neoplasia: Cross-Sectional Prevalence and Modulation by Celecoxib

2. Chemoprevention with Folic Acid

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