Search Clinical Trials
By Condition
By Location (USA)
By Location (Other)
By Sponsor
Resources
Privacy Policy
About Us
Disclaimer
Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy Clinical Trials References presented on Clinical Trials Search is not intended to be a substitute for proven healthcare advice, trips or professional assistance by using a real medical. We aren't mDs. Always confer with your physician about Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy Clinical research trials and Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the effectualness of new does drugs. The purpose of the studies / projects is to solve specific human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to discover treatments for all sorts of conditions, such as Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy. Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy Clinical Trials and other clinical trials permit volunteers to access healthcare treatment choices before they are available to the general public. Some times the subjects recieve professional assistance for without cost, and every now and again they are compensated for their time. Sometimes there is a cost for a Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy clinical trial. Subjects often receive the most expert healthcare possible for their Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy condition. Risks are a reality, nevertheless, and could include additional or frequent dr. calls, healthcare dangers (perhaps life-jeopardising), and/or the treatment being ineffective. Trials are federally governed with stern guidelines to protect clinical trials subjects.

Home > "C" Clinical Trials Conditions > Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy

Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy



Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy

For Condition: Pulmonary Complications,limited stage small cell lung cancer,Non-small cell lung cancer,Radiation Fibrosis
Status: Recruiting
Sponsor(s): Radiation Therapy Oncology Group , National Cancer Institute (NCI)
Synopsis: RATIONALE: Captopril is a drug that may be able to decrease side effects caused by radiation therapy, and may improve the quality of life of patients who have non-small cell lung cancer or limited-stage small cell lung cancer. PURPOSE: Randomizedphase II trial to determine the effectiveness of captopril in decreasing side effects and improving the quality of life in patients who have received radiation therapy with or without chemotherapy for stage I, stage II, or stage IIIB non-small cell lung cancer or limited-stage small cell lung cancer.
Details: OBJECTIVES: - Determine the effect of captopril on the incidence of pulmonary damage at 12 months after radiotherapy with or without chemotherapy in patients with stage II-IIIB non-small cell lung cancer, stage I central non-small cell lung cancer, or limited stage small cell lung cancer. - Compare the quality of life of patients treated with captopril vs patients who undergo post-radiotherapy observation only. - Determine the persistence of captopril's effect on pulmonary toxicity in these patients. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to participating center, total lung irradiated (25-37% vs more than 37%), prior surgery (yes vs no), and prior chemotherapy (yes vs no). Patients are randomized to 1 of 2 treatment arms. - Arm I: Patients receive oral captopril 3 times daily for 1 year in the absence of disease progression or unacceptable toxicity. - Arm II: Patients undergo observation only for 1 year. Quality of life is assessed at baseline and at months 3, 6, 12, and 18. Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter. PROJECTED ACCRUAL: A total of 205 patients will be accrued for this study within 18 months.
Eligibility:
Study Type:
  Interventional, Treatment
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - One of the following histologically or cytologically confirmed diagnoses: - Stage II-IIIB non-small cell lung cancer (NSCLC) - Stage I central NSCLC - No peripheral coin lesions - Limited stage small cell lung cancer - Nonmetastatic disease that is receiving radiotherapy and the target is confined to a single radiotherapy treatment area - Planning to receive radiotherapy - At least 45 Gy to be delivered to the target volume - More than 25% of total lung volume to receive greater than 20 Gy PATIENT CHARACTERISTICS: Age - 18 and over Performance status - Zubrod 0-1 Life expectancy - At least 6 months Hematopoietic - Absolute granulocyte count greater than 2,000/mm^3 - Platelet count greater than 100,000/mm^3 - Hemoglobin greater than 9.0 g/dL (transfusion allowed) Hepatic - Bilirubin less than 1.5 mg/dL - SGOT less than 2 times normal Renal - BUN less than 25 mg/dL - Creatinine less than 1.6 mg/dL - Urine protein less than 10 mg/dL - Urine glucose negative Cardiovascular - Systolic blood pressure greater than 110 mm Hg - Diastolic blood pressure greater than 60 mm Hg Other - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective contraception - Sodium 135-148 mEq/L - Potassium 3.5-5.0 mEq/L - No collagen vascular disease (e.g., lupus or scleroderma) - Rheumatoid arthritis allowed - No known hypersensitivity to ACE inhibitors PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - Induction or concurrent chemotherapy allowed - No concurrent methotrexate Endocrine therapy - Not specified Radiotherapy - See Disease Characteristics Surgery - Prior pulmonary lobectomy or segmentectomy allowed - No prior pneumonectomy Other - No concurrent angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor antagonists for hypertension or congestive heart failure - No concurrent enrollment on other cooperative group or single institution protocols using radiotherapy with or without chemotherapy - No concurrent lithium - No concurrent procainamide - No concurrent anticancer therapy
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
WilliamSmall,  Study Chair,  Robert H. Lurie Cancer Center

Newark Beth Israel Medical Center *Recruiting*
Newark,  New Jersey,  07112
United States
Recruiting Robert  Ivker 201-926-7320

CCOP - Dayton *Recruiting*
Dayton,  Ohio,  45429
United States
Recruiting Howard  Gross 937-395-8678

Fairfield Medical Center *Recruiting*
Lancaster,  Ohio,  43130
United States
Recruiting Contact  Person 800-548-2624

Bay Area Cancer Care Center at Bay Area Medical Center *Recruiting*
Marinette,  Wisconsin,  54143
United States
Recruiting Contact  Person 715-735-6621

Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha *Recruiting*
Omaha,  Nebraska,  68114-4199
United States
Recruiting James  Wheeler 402-354-4104

Hematology Oncology Associates of Central New York, P.C. - East Syracuse *Recruiting*
East Syracuse,  New York,  13057
United States
Recruiting Contact  Person 315-472-7504

Delaware County Memorial Hospital *Recruiting*
Drexel Hill,  Pennsylvania,  19026
United States
Recruiting Rachelle  Lanciano 610-284-8240

CCOP - Greenville *Recruiting*
Greenville,  South Carolina,  29615
United States
Recruiting Michael  Zurenko 864-241-6251

LDS Hospital *Recruiting*
Salt Lake City,  Utah,  84143
United States
Recruiting William  Sause 801-408-1146

Riverside Methodist Hospital *Recruiting*
Columbus,  Ohio,  43214-3998
United States
Recruiting Contact  Person 614-566-5000

St. Francis Women's & Family Hospital *Recruiting*
Greenville,  South Carolina,  29615
United States
Recruiting Contact  Person 864-675-4029

Mary Bird Perkins Cancer Center *Recruiting*
Baton Rouge,  Louisiana,  70809
United States
Recruiting Kenneth  Lo 225-767-0847

Wayne Memorial Hospital, Inc. *Recruiting*
Goldsboro,  North Carolina,  27533
United States
Recruiting Contact  Person 919-736-1110

Dixie Regional Medical Center *Recruiting*
St. George,  Utah,  84770
United States
Recruiting Ray  Richards 801-688-4175

Mobile Infirmary Medical Center *Recruiting*
Mobile,  Alabama,  36652-2144
United States
Recruiting Contact  Person 251-435-2400

Pomona Valley Hospital Medical Center *Recruiting*
Pomona,  California,  91767
United States
Recruiting Contact  Person 909-865-9500

Beebe Medical Center *Recruiting*
Lewes,  Delaware,  19958
United States
Recruiting Contact  Person 302-645-3770

Shands Cancer Center at the University of Florida Health Science Center *Recruiting*
Gainesville,  Florida,  32610-0385
United States
Recruiting William  Mendenhall 352-265-0287

St. John's Regional Health Center *Recruiting*
Springfield,  Missouri,  65804-2263
United States
Recruiting Contact  Person 417-885-2000

Margaret Pardee Memorial Hospital *Recruiting*
Hendersonville,  North Carolina,  28791
United States
Recruiting Contact  Person 828-696-1000

Licking Memorial Hospital *Recruiting*
Newark,  Ohio,  43055-2899
United States
Recruiting Contact  Person 740-348-4000

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center *Recruiting*
Spartanburg,  South Carolina,  29303
United States
Recruiting Contact  Person 864-560-6747

St. Mary's Hospital *Recruiting*
Milwaukee,  Wisconsin,  53201
United States
Recruiting Contact  Person 414-885-2000

CCOP - Ochsner *Recruiting*
New Orleans,  Louisiana,  70121
United States
Recruiting Carl  Kardinal 504-842-3910

CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. *Recruiting*
Syracuse,  New York,  13217
United States
Recruiting N.  Mariados 315-472-7504

Lankenau Cancer Center at Lankenau Hospital *Recruiting*
Wynnewood,  Pennsylvania,  19096
United States
Recruiting Contact  Person 610-645-2680

CCOP - Christiana Care Health Services *Recruiting*
Newark,  Delaware,  19713
United States
Recruiting Christopher  Koprowski 302-733-1830

Baton Rouge General Medical Center *Recruiting*
Baton Rouge,  Louisiana,  70821-2511
United States
Recruiting Contact  Person 225-387-7000

CCOP - Beaumont *Recruiting*
Royal Oak,  Michigan,  48073-6769
United States
Recruiting John  Robertson 248-551-7038

Trinity Cancer Care Center *Recruiting*
Minot,  North Dakota,  58701
United States
Recruiting Kevin  Collins 701-857-3535

McKay-Dee Hospital Center *Recruiting*
Ogden,  Utah,  84403
United States
Recruiting Contact  Person 801-627-2800

Robert H. Lurie Comprehensive Cancer Center at Northwestern University *Recruiting*
Chicago,  Illinois,  60611-3013
United States
Recruiting William  Small 312-926-6810

Anderson Area Cancer Center *Recruiting*
Anderson,  South Carolina,  29621-5705
United States
Recruiting Contact  Person 800-613-5631

Baptist Regional Cancer Institute - Jacksonville *Recruiting*
Jacksonville,  Florida,  32207
United States
Recruiting Contact  Person 904-247-2900

Indiana University Cancer Center *Recruiting*
Indianapolis,  Indiana,  46202-5289
United States
Recruiting Contact  Person 888-600-4822

West Michigan Cancer Center *Recruiting*
Kalamazoo,  Michigan,  49007
United States
Recruiting Contact  Person 616-373-7488

Memorial Hospital Cancer Center *Recruiting*
Colorado Springs,  Colorado,  80909
United States
Recruiting Contact  Person 719-365-6800

Strecker Cancer Center at Marietta Memorial Hospital *Recruiting*
Marietta,  Ohio,  45750-1635
United States
Recruiting Contact  Person 740-374-1400

Paoli Memorial Hospital *Recruiting*
Paoli,  Pennsylvania,  19301-1792
United States
Recruiting Contact  Person 610-648-1637

St. Vincent Hospital *Recruiting*
Green Bay,  Wisconsin,  54307-3508
United States
Recruiting Gregory  Cooley 414-433-8184

Rutherford Hospital *Recruiting*
Rutherfordton,  North Carolina,  28139-0000
United States
Recruiting Contact  Person 828-286-5000

Doctors Hospital - Ohio Health *Recruiting*
Columbus,  Ohio,  43228
United States
Recruiting Contact  Person 614-297-4000

CCOP - MainLine Health *Recruiting*
Wynnewood,  Pennsylvania,  19096
United States
Recruiting Albert  DeNittis 610-645-2433

St. Luke's Hospital Cancer Center *Recruiting*
Bethlehem,  Pennsylvania,  18015
United States
Recruiting Nimisha  Deb 610-954-4300

Marshfield Clinic *Recruiting*
Marshfield,  Wisconsin,  54449
United States
Recruiting Warren  Olds 715-387-7637

CCOP - Bay Area Tumor Institute *Recruiting*
Oakland,  California,  94609-3305
United States
Recruiting Brenda  Shank 510-456-8570

Sarasota Radiation and Medical Oncology Center *Recruiting*
Sarasota,  Florida,  34233
United States
Recruiting W.  Dickens 941-924-8700

Adena Regional Medical Center *Recruiting*
Chillicothe,  Ohio,  45601
United States
Recruiting Contact  Person 740-779-7500

Community Hospital of Springfield and Clark County *Recruiting*
Springfield,  Ohio,  45505
United States
Recruiting Contact  Peson 937-325-0531

Foundation for Cancer Research and Education *Recruiting*
Phoenix,  Arizona,  85013
United States
Recruiting David  Brachman 602-274-4484

Hulston Cancer Center at Cox Medical Center South *Recruiting*
Springfield,  Missouri,  65807
United States
Recruiting Contact  Person 417-269-5257

CCOP - Columbus *Recruiting*
Columbus,  Ohio,  43206
United States
Recruiting Lawrence  Berk 614-566-9506

Ireland Cancer Center *Recruiting*
Cleveland,  Ohio,  44106-5065
United States
Recruiting Adir  Ludin 216-844-5432

Mercy Medical Center *Recruiting*
Canton,  Ohio,  44708
United States
Recruiting Contact  Person 330-489-1105

Cooper University Hospital *Recruiting*
Camden,  New Jersey,  08103
United States
Recruiting Contact  Person 800-8-Cooper

Grady Memorial Hospital *Recruiting*
Delaware,  Ohio,  43015
United States
Recruiting Contact  Person 740-368-5383

Utah Valley Regional Medical Center - Provo *Recruiting*
Provo,  Utah,  84604
United States
Recruiting Tarlton  Blair 801-373-7850 ext. 2480

University of Colorado Cancer Center at University of Colorado Health Sciences Center *Recruiting*
Denver,  Colorado,  80010
United States
Recruiting Rachel  Rabinovitch 720-848-0116

Presbyterian Hospital *Recruiting*
Charlotte,  North Carolina,  28233-3549
United States
Recruiting Contact  Person 704-384-4000

Bryn Mawr Hospital *Recruiting*
Bryn Mawr,  Pennsylvania,  19010
United States
Recruiting Contact  Person 610-526-3686

Fox Chase Cancer Center *Recruiting*
Philadelphia,  Pennsylvania,  19111
United States
Recruiting Benjamin  Movsas 215-728-3631

Nanticoke Memorial Hospital *Recruiting*
Seaford,  Delaware,  19973
United States
Recruiting Contact  Person 302-629-0260

CCOP - Scott and White Hospital *Recruiting*
Peoria,  Illinois,  61602
United States
Recruiting Cathy  Clausen 309-636-3605

University Hospitals of Cleveland *Recruiting*
Cleveland,  Ohio,  44106
United States
Recruiting Janice  Lyons 216-844-2536

Mercy Hospital of Pittsburgh *Recruiting*
Pittsburgh,  Pennsylvania,  15219
United States
Recruiting Michael  Dougherty 412-232-7862

Cottonwood Hospital Medical Center *Recruiting*
Murray,  Utah,  84107
United States
Recruiting Contact  Person 801-314-5300


Additional Information:
Study ID Numbers:
  CDR0000315569;  RTOG-L-0123,RTOG-0123
Study Start Date: 
Record last reviewed: January 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00077064

Other Non-Small Cell Lung Cancer Studies:
1. Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer

2. Study of Pulmonary Complications in Pediatric Patients With Storage Disorders Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

3. Standard Chest Tube Compared With a Small Catheter in Treating Malignant Pleural Effusion in Patients With Cancer

4. Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Disease

5. Buspirone in Reducing Shortness of Breath in Patients With Cancer

Related Studies:

Other Non-small cell lung cancer Clinical Trials
Other Ohio Clinical Trials
Other Newark Clinical Trials

Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy

Modify your Search

  Other Non-small cell lung cancer Clinical Trials
  Other Ohio Clinical Trials
  Other Newark Clinical Trials


Warning: include(/var/www/cgi-bin/traxis/counter.php) [function.include]: failed to open stream: No such file or directory in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103

Warning: include() [function.include]: Failed opening '/var/www/cgi-bin/traxis/counter.php' for inclusion (include_path='.:/usr/local/lib/php') in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103