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Brain Cell Injury in Patients With A First Episode of Psychosis



Brain Cell Injury in Patients With A First Episode of Psychosis

For Condition: Psychoses
Status: Recruiting
Sponsor(s): National Center for Complementary and Alternative Medicine (NCCAM) ,
Synopsis: Patients experiencing a first episode of psychosis may have brain cell damage due to a chemical process called oxidation. This study will compare patients with psychosis to healthy volunteers to determine if there are differences in their blood that reflect oxidative brain cell damage.
Details: Preliminary research indicated that impaired antioxidant defense and increased lipid peroxidation is associated with brain changes during the onset of psychosis. Oxidative cell injury may contribute to poor outcomes in some patients. This study will define the extent and nature of oxidative cell injury that is associated with psychopathology at the onset of psychosis. Participants in this study will be patients at the D. D. Eisenhower Army Medical Center who are experiencing a psychotic episode for the first time. Patients will be compared with 40 healthy volunteers (control group) matched with patients for age, gender, education, ethnic background, and occupational status. Patients and volunteers will have blood tests to determine the level of oxidative cell injury. Tests will be performed at onset of psychosis, and after 6 and 12 weeks of neuroleptic drug treatment. Medical histories and MRI scans will be used to examine the relationship of the laboratory tests to the clinical presentation.
Eligibility:
Study Type:  Observational, Screening, Longitudinal, Defined Population, Prospective Study
Minimum Age/Maximum Age: 12 Years/45 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria - Patients must meet clinical diagnostic criteria for psychosis - Healthy (control) volunteers must not have any family history of mental illness
Total Enrollment: 30

Location and Contact Information:

Overall Study Official:
SahebraoMahadik,  Principal Investigator,  Medical College of Georgia

Medical College of Georgia *Recruiting*
Augusta,  Georgia,  30912
United States
Recruiting Sahebrao  Mahadik 706-733-0188


Additional Information:
Study ID Numbers:  1 R01 AT00147-01; 
Study Start Date: September 1999
Record last reviewed: September 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00070889

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