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Behavioral Therapy Plus Naltrexone for Alcoholism Clinical Trials Info presented on Clinical Trials Search is not intended to be a substitute for certified medical advice, visits or professional assistance using a real physician. We are not physicians. Always consult your dr. about Behavioral Therapy Plus Naltrexone for Alcoholism conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Behavioral Therapy Plus Naltrexone for Alcoholism Clinical research trials and Behavioral Therapy Plus Naltrexone for Alcoholism health trials happen in many of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new drugs. The function of the studies / projects is to resolve particular human medical questions. Clinical trials are a popular manner for mDs, government agencies, and private sector corporations to discover remedies for all varieties of circumstances, like Behavioral Therapy Plus Naltrexone for Alcoholism. Behavioral Therapy Plus Naltrexone for Alcoholism Clinical Trials and other clinical trials allow volunteers to obtain healthcare treatment options before they are available to the masses. Some times the participants undergo professional assistance for free of charge, and occasionally they are paid for their time. Sometimes there is a cost for a Behavioral Therapy Plus Naltrexone for Alcoholism clinical trial. Human subjects often get the best healthcare available for their Behavioral Therapy Plus Naltrexone for Alcoholism condition. Dangers are a reality, however, and may include additional or frequent mD visits, healthcare dangers (potentially life-jeopardising), and/or the treatment being ineffectual. Trials are federally governed with rigorous guidelines to protect clinical trials patients.
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Home > "B" Clinical Trials Conditions > Behavioral Therapy Plus Naltrexone for Alcoholism  Behavioral Therapy Plus Naltrexone for Alcoholism
Behavioral Therapy Plus Naltrexone for Alcoholism
For Condition: Alcoholism
Status: Recruiting
Sponsor(s): National Institute on Alcohol Abuse and Alcoholism (NIAAA) ,
Synopsis: This study will compare cognitive behavioral therapy with a time-limited motivational enhancement therapy to which naltrexone (Revia) or placebo medication is added. In this randomized clinical trial, 160 alcohol-dependent outpatients, after 5 days of abstinence, will receive one of the two psychosocial therapies and either naltrexone (Revia) or placebo for a 12-week treatment period. Abstinence rates, alcohol use, and time to alcohol relapse will be evaluated in all four groups along with measures of alcohol craving, biological measures of alcohol consumption, drinking consequences, changes in self-confidence for avoiding alcohol, and medication compliance. All study participants will be assessed for measures of outcome variables at 3 and 6 months after completing the treatment protocol.
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized, Open Label, Placebo Control, Parallel Assignment, Efficacy Study
Minimum Age/Maximum Age: 21 Years/70 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Meets criteria for alcohol dependence, has not had more than one previous inpatient medical detoxification. - Consumes on average five standard drinks per day. - Able to maintain sobriety for five days (with or without the aid of detoxification medications) as determined by self-report, collateral report, and breathalyzer measurements. - Able to read and understand questionnaires and informed consent. - Lives within 50 miles of the study site. Exclusion Criteria: - Currently meets criteria for any other psychoactive substance dependency disorder. - Ever abused opiates. - Used psychoactive substance abuse, except marijuana, within the last 30 days as evidenced by patient report, collateral report, and urine drug screen. - Meets criteria for disorders of major depression, panic disorder, obsessive-compulsive disorder, post-traumatic stress syndrome, bipolar affective disorder, schizophrenia, or any other psychotic disorder or organic mental disorder. - Meets criteria for dissociate disorder or eating disorders. - Has current suicidal or homicidal ideation. - Need for maintenance or acute treatment with any psychoactive medication including antiseizure medications. - Current use of disulfiram (Antabuse). - Clinically significant medical problems that would impair participation or limit medication ingestion. - Hepatocellular disease. - Sexually active females of child bearing potential who are pregnant, nursing, or who are not using a reliable form of birth control. - Have current charges pending for a violent crime. - Does not have a stable living situation and a reliable source of collateral reporting. - Has taken an opiate antagonist drug in the last month.
Total Enrollment: 160
Location and Contact Information:
Medical Univ. of South Carolina *Recruiting*
Charleston, South Carolina, 29425
United States
Recruiting Dr. Anton 843-792-1226
Additional Information:
Study ID Numbers: NIAAAANT09568;
Study Start Date:
Record last reviewed: March 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00000456
Other Alcoholism Studies:
1. Sertraline and Cognitive Therapy in Depressed Alcoholics
2. Treatment for Alcoholism and Post-Traumatic Stress Disorder (naltrexone)
3. Preliminary Human Trial of NPI-028
4. Treating Alcohol Use In Older Adults With Depression
5. Tobacco Dependence in Alcoholism Treatment (nicotine patch/naltrexone)
Related Studies:
Other Alcoholism Clinical Trials
Other South Carolina Clinical Trials
Other Charleston Clinical Trials
Behavioral Therapy Plus Naltrexone for Alcoholism
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