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Atherosclerosis in the Coronary and Carotid Arteries: Correlations between Coronary IVUS, Carotid Ultrasound, and Carotid MRI Clinical Trials References presented on Clinical Trials Search isn't meant to be a substitute for proven healthcare advice, trips or professional assistance using a genuine physician. We are not docs. Always confer with your physician about Atherosclerosis in the Coronary and Carotid Arteries: Correlations between Coronary IVUS, Carotid Ultrasound, and Carotid MRI conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Atherosclerosis in the Coronary and Carotid Arteries: Correlations between Coronary IVUS, Carotid Ultrasound, and Carotid MRI Clinical research trials and Atherosclerosis in the Coronary and Carotid Arteries: Correlations between Coronary IVUS, Carotid Ultrasound, and Carotid MRI healthcare trials happen in hundreds of localities throughout the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the potency of new drugs. The propose of the studies / projects is to answer particular human health questions. Clinical trials are a popular way for mDs, government agencies, and private sector companies to detect cures for all sorts of conditions, such as Atherosclerosis in the Coronary and Carotid Arteries: Correlations between Coronary IVUS, Carotid Ultrasound, and Carotid MRI. Atherosclerosis in the Coronary and Carotid Arteries: Correlations between Coronary IVUS, Carotid Ultrasound, and Carotid MRI Clinical Trials and other clinical trials allow volunteers to acquire healthcare treatment choices before they are available to the general public. Some times the subjects recieve professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Atherosclerosis in the Coronary and Carotid Arteries: Correlations between Coronary IVUS, Carotid Ultrasound, and Carotid MRI clinical trial. Subjects frequently obtain the most expert healthcare possible for their Atherosclerosis in the Coronary and Carotid Arteries: Correlations between Coronary IVUS, Carotid Ultrasound, and Carotid MRI condition. Risks are a reality, nevertheless, and can include more or frequent doctor trips, medical risks (possibly life-threatening), and/or the treatment being uneffective. Trials are federally governed with stern guidelines to protect clinical trials patients.
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Home > "A" Clinical Trials Conditions > Atherosclerosis in the Coronary and Carotid Arteries: Correlations between Coronary IVUS, Carotid Ultrasound, and Carotid MRI  Atherosclerosis in the Coronary and Carotid Arteries: Correlations between Coronary IVUS, Carotid Ultrasound, and Carotid MRI
Atherosclerosis in the Coronary and Carotid Arteries: Correlations between Coronary IVUS, Carotid Ultrasound, and Carotid MRI
For Condition:
Status: Recruiting
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: Under the general hypothesis that atherosclerosis is a systemic disease; the purpose of this protocol is to compare coronary artery atherosclerotic abnormalities with carotid artery abnormalities. This is an NHLBI sponsored sub study to the Pfizer sponsored trial comparing atorvastatin or the combination of atorvastatin/CETP inhibitor as treatments for patients with coronary heart disease. The primary study is a multicenter, randomized, double blind, active-controlled study which uses intracoronary ultrasound to measure coronary plaque volume during the course of treatment. The scientific value of the NHLBI sub study will be the comparison of atherosclerotic abnormalities in two different vascular beds, the coronary artery and the carotid arteries. This study will examine correlations between invasive coronary measurements by intravascular ultrasound (IVUS), with 2-dimensional measurements of wall thickness by carotid intimal medial wall thickness (IMT), and with 3-dimensional measurements of carotid wall volume by MRI and 3D ultrasound. Secondary analysis will probe whether carotid plaque characteristics can predict atheroma regression. Secondary analysis will also assess the ability of noninvasive carotid measures to predict the degree of coronary regression determined in the coronary arteries by IVUS. It is important to note that the NHLBI study design remains blinded to the treatment group a subject is enrolled in since the sample size for a single center study is too small to detect the conservatively estimated additional benefit of combination atorvastatin/CETP inhibitor treatment over the already effective atorvastatin alone. Thus, the NHLBI sub study is primarily a pathophysiological study correlating carotid and coronary atherosclerotic changes as well as a technological comparison of IVU, carotid IMT, and carotid vessel wall volume by MRI. If successful, this study could provide the framework for following treatment trials of this nature with noninvasive tools, either ultrasound or MRI, in place of the accurate but invasive IVUS.
Details: Under the general hypothesis that atherosclerosis is a systemic disease; the purpose of this protocol is to compare coronary artery atherosclerotic abnormalities with carotid artery abnormalities. This is an NHLBI sponsored sub study to the Pfizer sponsored trial comparing atorvastatin or the combination of atorvastatin/CETP inhibitor as treatments for patients with coronary heart disease. The primary study is a multicenter, randomized, double blind, active-controlled study which uses intracoronary ultrasound to measure coronary plaque volume during the course of treatment. The scientific value of the NHLBI sub study will be the comparison of atherosclerotic abnormalities in two different vascular beds, the coronary artery and the carotid arteries. This study will examine correlations between invasive coronary measurements by intravascular ultrasound (IVUS), with 2-dimensional measurements of wall thickness by carotid intimal medial wall thickness (IMT), and with 3-dimensional measurements of carotid wall volume by MRI and 3D ultrasound. Secondary analysis will probe whether carotid plaque characteristics can predict atheroma regression. Secondary analysis will also assess the ability of noninvasive carotid measures to predict the degree of coronary regression determined in the coronary arteries by IVUS. It is important to note that the NHLBI study design remains blinded to the treatment group a subject is enrolled in since the sample size for a single center study is too small to detect the conservatively estimated additional benefit of combination atorvastatin/CETP inhibitor treatment over the already effective atorvastatin alone. Thus, the NHLBI sub study is primarily a pathophysiological study correlating carotid and coronary atherosclerotic changes as well as a technological comparison of IVU, carotid IMT, and carotid vessel wall volume by MRI. If successful, this study could provide the framework for following treatment trials of this nature with noninvasive tools, either ultrasound or MRI, in place of the accurate but invasive IVUS.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA Patients will be a subset of patients participating in the multicenter IVUS protocol. Willingness to travel to the NIH to participate in the NHLBI MRI/IMT study. EXCLUSION CRITERIA Pacemaker Defibrillator Brain aneurysm clips Implanted active medical devices (neural stimulators, cochlear implants, insulin pumps, etc.) Severe claustrophobia Allergy to gadolinium based contrast agents (only excludes the gadolinium portion of the test)
Total Enrollment: 125
Location and Contact Information:
National Heart, Lung and Blood Institute (NHLBI) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 040154; 04-H-0154
Study Start Date: April 2, 2004
Record last reviewed: March 30, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00080587
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Atherosclerosis in the Coronary and Carotid Arteries: Correlations between Coronary IVUS, Carotid Ultrasound, and Carotid MRI
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