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Antipsychotic Response in Schizophrenia



Antipsychotic Response in Schizophrenia

For Condition: Schizophrenia
Status: Recruiting
Sponsor(s): Department of Veterans Affairs Medical Research Service ,
Synopsis: Motor slowing is a hallmark, clinical sign in mental illness. Slowness can be related to a specific disease process, as in negative schizophrenia or depression or it can be the result of medications used to treat forms of mental illness. Prior research has lead to a novel instrumental approach for distinguishing subtypes of motor slowing - one type related to cognitive processes and another related to parkinsonism. The purpose of this study is to test whether new medications used to treat schizophrenia improve the cognitive or parkinsonian components of motor slowing. Patients will be studied in the laboratory before and 8-weeks after starting a new antipsychotic. The n of this study = 60 patients. The results of this study will improve our understanding of the complex interactions between cognitive processing and motor behavior in patients with psychotic illnesses and how drugs work to treat these problems.
Details:
Eligibility:
Study Type:
  Interventional, Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study
Minimum Age/Maximum Age: 21 Years/70 Years
Genders: Both
Protocol Entry Criteria: Schizophrenia diagnosis currently treated with conventional antipsychotic willing to be switched to an atypical antipsychotic.
Total Enrollment: 

Location and Contact Information:

Department of Veterans Affairs *Recruiting*
San Diego,  California,  92161
United States
Recruiting Michael  Caligiuri 858-552-8585


Additional Information:
Study ID Numbers:
  MHBS-041-00S; 
Study Start Date: October 2000
Record last reviewed: June 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00018668

Other Schizophrenia Studies:
1. Depakote ER plus an atypical antipsychotic vs. an atypical antipsychotic alone in the treatment of schizophrenia

2. Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers

3. Improving Health Services for Veterans with Schizophrenia

4. A Comparison of Study Drug with Placebo and Haloperidol in Patients With Schizophrenia

5. Trial Evaluating the Safety and Efficacy of 2 Doses of ER OROS Paliperidone in Acute Adult Schizophrenics

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Antipsychotic Response in Schizophrenia

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