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Home > "A" Clinical Trials Conditions > Antidepressant Treatment in Late Life Schizophrenia  Antidepressant Treatment in Late Life Schizophrenia
Antidepressant Treatment in Late Life Schizophrenia
For Condition: Schizophrenia
Status: Recruiting
Sponsor(s): National Institute of Mental Health (NIMH) ,
Synopsis: The purpose of this study is to evaluate the safety and effectiveness of citalopram (Celexa) for the treatment of depressive symptoms in middle-aged and elderly patients with schizophrenia.
Details: Older people with schizophrenia suffer from greater physical comorbidity, cognitive impairment, and medication side effects compared to their younger counterparts. Unfortunately, little research is available to guide the treatment of subsyndromal depressive symptoms in older adults. This study will compare the antidepressant citalopram to placebo to determine the most effective treatment for reducing depressive symptoms. After patients have been on stable treatment with antipsychotic medication for at least 4 weeks, they are randomly assigned to receive antipsychotic medication plus either citalopram or placebo for 3 months. Depressive symptoms and side effects are assessed weekly for the first month, biweekly for the second month, and again at the end of the third month. Cognition, motor and daily functioning, quality of life, and medication adherence are assessed throughout the study.
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: 45 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Schizophrenia or schizoaffective disorder - HAM-D score of 8 or above - Antipsychotic medication treatment
Total Enrollment: 240
Location and Contact Information:
Overall Study Official:
JohnKasckow, Principal Investigator, University of Cincinnati
Veterans Administration Hospital of Cincinnati *Recruiting*
Cincinnati, Ohio, 45220
United States
Recruiting John Kasckow 513-861-3100
University of California, San Diego *Recruiting*
San Diego, California,
United States
Recruiting Sid Zisook 858-534-4040
Additional Information:
Study ID Numbers: 63798-01;
Study Start Date: September 2001
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00046098
Other Schizophrenia Studies:
1. Cognitive Behavioral Therapy for Post-Traumatic Stress Disorder in Individuals with Severe Mental Illness
2. 3 Fixed Dosages of Extended Release OROS Paliperidone and Olanzapine in the Treatment of Subjects with Schizophrenia
3. Brain Tissue Collection for Neuropathological Studies
4. Extended Release OROS Paliperidone in treatment of Schizophrenia (double blind, placebo-controlled trial, with Olanzapine arm)
5. Safety and efficacy of study drug versus placebo for negative symptoms of schizophrenia
Related Studies:
Other Schizophrenia Clinical Trials
Other California Clinical Trials
Other San Diego Clinical Trials
Antidepressant Treatment in Late Life Schizophrenia
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