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Anticoagulation, Vitamins, and Endothelial Function Clinical Trials References presented on Clinical Trials Search isn't meant to be a substitute for proven healthcare advice, trips or professional assistance using a genuine physician. We are not docs. Always confer with your physician about Anticoagulation, Vitamins, and Endothelial Function conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Anticoagulation, Vitamins, and Endothelial Function Clinical research trials and Anticoagulation, Vitamins, and Endothelial Function healthcare trials happen in hundreds of localities throughout the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the potency of new drugs. The propose of the studies / projects is to answer particular human health questions. Clinical trials are a popular way for mDs, government agencies, and private sector companies to detect cures for all sorts of conditions, such as Anticoagulation, Vitamins, and Endothelial Function. Anticoagulation, Vitamins, and Endothelial Function Clinical Trials and other clinical trials allow volunteers to acquire healthcare treatment choices before they are available to the general public. Some times the subjects recieve professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Anticoagulation, Vitamins, and Endothelial Function clinical trial. Subjects frequently obtain the most expert healthcare possible for their Anticoagulation, Vitamins, and Endothelial Function condition. Risks are a reality, nevertheless, and can include more or frequent doctor trips, medical risks (possibly life-threatening), and/or the treatment being uneffective. Trials are federally governed with stern guidelines to protect clinical trials patients.
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Home > "A" Clinical Trials Conditions > Anticoagulation, Vitamins, and Endothelial Function  Anticoagulation, Vitamins, and Endothelial Function
Anticoagulation, Vitamins, and Endothelial Function
For Condition: Cardiovascular Diseases
Status: Recruiting
Sponsor(s): Department of Veterans Affairs Medical Research Service ,
Synopsis: Determine whether low or high dose B vitamin therapy will lower homocysteine and thrombomodulin in patients anticoagulated with warfarin.
Details: We hypothesize that 1) both high and low dose B vitamin therapy will lower homocysteine in patients anticoagulated with warfarin and 2) high dose B vitamin therapy will lower thrombomodulin in patients anticoagulated with warfarin. To accomplish these specific aims, we proposed a double- blind randomized controlled trial of 6 months duration comparing 2 different multivitamin regimens differing only in the doses of the following 3 vitamins. The multivitamin for the control group has no folic acid, B2, B6, or B 12. The multivitamin for the intervention group has 5 ing folic acid, 1.7 mg B2, 100 mg B6, and I mg B12. Participants age 50 and older, 150 in each group, are being recruited from the Anticoagulation Clinics at the Baltimore VAMC and neighboring centers. Clinical and risk factor information is being obtained through a face-to-face interview. Blood is being drawn for analyses of homocysteine and vitamin levels (University of Colorado Health Science Center) and thrombomodulin (Baltimore VAMC Hemostasis and Thrombosis Laboratory). Data analysis will be conducted according to the "intention to treat" principle using ordinary least squares regression models.
Eligibility:
Study Type: Interventional, Prevention, Randomized, Double-Blind, Placebo Control, Single Group Assignment, Efficacy Study
Minimum Age/Maximum Age: 50 Years/95 Years
Genders: Both
Protocol Entry Criteria: Males and females ages 50 years or greater On warfarin therapy for at least 3 months No active inflammatory process No physician prescribed B vitamins Excluded - women of child-bearing age
Total Enrollment:
Location and Contact Information:
VA Maryland Health Care System *Recruiting*
Baltimore, Maryland, 21201
United States
Recruiting Steven Kittner 410-706-0414
Additional Information:
Study ID Numbers: Epid-004-98F;
Study Start Date: April 1999
Record last reviewed: June 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00018460
Other Cardiovascular Diseases Studies:
1. Computer Assisted Instruction Weight Management for Low Literacy Populations
2. Low Cholesterol and Mortality in Blacks and Women
3. Harvard Atherosclerosis Reversibility Project (HARP)
4. Behavioral Factors in Coronary Heart Disease
5. Community Site Coronary Risk Control in Black Families
Related Studies:
Other Cardiovascular Diseases Clinical Trials
Other Maryland Clinical Trials
Other Baltimore Clinical Trials
Anticoagulation, Vitamins, and Endothelial Function
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