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Home > "A" Clinical Trials Conditions > Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers  Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers
Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers
For Condition: Cardiomyopathy, Hypertrophic,Coronary Disease,Healthy,Myocardial Ischemia,Syndrome X
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: Myocardial ischemia is a heart condition in which not enough blood supply and oxygen reaches the heart muscle. Damage to the major blood vessels of the heart (coronary artery disease), minor blood vessels of the heart (microvascular heart disease), or damage to the heart muscle (hypertrophic cardiomyopathy) can cause myocardial ischemia. Any of theses three conditions can cause patients to experience chest pain and other symptoms as well as cause the heart to function improperly. In order to detect myocardial ischemia researchers can use tests to measure the movement of the walls of the heart. Walls receiving inadequate supplies of blood often move less and occasionally move in the opposite direction. Some of the tests may require patients to receive injections of radioactive tracers. The radioactive material acts to enhance 3 dimensional pictures of the heart and helps to identify areas of ischemia. The purpose of this study is to determine whether 3-dimensional imaging (tomography) with radioactive tracers can provide more important information about heart wall function than routine diagnostic tests.
Details: We propose to assess regional myocardial function using gated blood pool imaging acquired by a tomographic technique at rest and during stress in patients with myocardial ischemia (coronary artery disease, hypertrophic cardiomyopathy and microvascular angina). Gender differences in response to exercise and pharmacologic stress will also be evaluated. Normal subjects will be studied in order to establish a control database. Current methods of gated blood pool studies use planar imaging, with its attendant limitations; poor resolution and inadequate separation of the myocardial segments, only one view assessed during exercise and superimposition of overlying structures. Tomographic imaging has the advantages of reconstructing 3-dimensional data of the entire heart with the ability to improve segmental resolution and separate overlapping structures, potentially resulting in increased sensitivity and specificity for detection of disease. The role of pharmacologic stress will be assessed by comparison with exercise stress, in order to validate its use in subjects unable to exercise and identify gender related differences. Quantitative measures of regional wall motion obtained from tomography will be compared to regions of prior myocardial infarction (if present), and with other modalities for evaluating cardiac structure and function. The diagnostic and prognostic value of tomographic wall motion analysis will be studied in patients with myocardial ischemia, with special emphasis on correlation between physiologic variables of coronary blood flow and metabolic function.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Patients with known coronary artery disease (obstruction of greater than or equal to 50% in at least one major coronary artery). Patients with hypertrophic cardiomyopathy. Patients with microvascular angina. No unstable angina. No hepatic or renal failure. Infective endocarditis No primary valvular disease. No congenital heart disease. No pregnant or breast feeding women.
Total Enrollment: 150
Location and Contact Information:
National Heart, Lung and Blood Institute (NHLBI)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 950048; 95-H-0048
Study Start Date: January 10, 1995
Record last reviewed: January 12, 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001459
Other Cardiomyopathy, Hypertrophic Studies:
1. The Role of Heart Stiff and Weak Atrium on Exercise Capacity in Patients with Hypertrophic Cardiomyopathy
2. Long-Term Results of DDD Pacing in Obstructive Hypertrophic Cardiomyopathy
3. Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers
4. Cyclosporine A to Treat Hypertrophic Cardiomyopathy (HCM)
Related Studies:
Other Cardiomyopathy, Hypertrophic Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Analysis of Heart Muscle Function in Patients with Heart Disease and Normal Volunteers
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