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Home > "A" Clinical Trials Conditions > Analysis of Eye Tissue  Analysis of Eye Tissue
Analysis of Eye Tissue
For Condition: Eye Disease,Inflammation,Uveitis
Status: Completed
Sponsor(s): National Eye Institute (NEI) ,
Synopsis: The purpose of this investigation is to better understand the inflammatory process that occurs in uveitis (eye inflammation) through study of eye tissues. Patients with uveitis sometimes develop cataracts (clouding of the lens of the eye) or clouding of the vitreous-the gel-like material behind the lens-that can impair eyesight. Those who require cataract surgery or vitrectomy are eligible for this study. Samples of eye tissue and fluid normally removed during standard surgical procedures for these conditions will be given to researchers instead of discarded, as is usually done. Before surgery, patients will undergo routine preoperative tests, including chest X-ray, electrocardiogram, blood tests and urinalysis. They will also have an eye examination and photographs taken of the retina. Other tests that may be performed include fluorescein angiography to evaluate the blood vessels of the retina; ultrasound to examine the back of the eye; and a gallium scan to evaluate inflammation. Immune cells in the blood and eye tissue will be compared and categorized by disease. The eye fluid will be examined for substances involved in the inflammatory process. These studies may provide information that will lead to improved methods of diagnosis and treatment.
Details: The purpose of this project is to evaluate intra-ocular tissue such as iris or vitreous from uveitis patients in order to analyze the type and character of the inflammatory response. Patients with a history of uveitis who require cataract surgery or vitreous surgery because of the clinical complications of inflammation, will be entered in this study. The lymphocyte subsets in the peripheral blood and ocular tissue will be compared and categorized by disease. The presence of soluble lymphokines in the intra-ocular fluid will be analyzed. Long term cell cultures of vitreal cells will be attempted to define the T-cell receptors. In addition, a portion of iris tissue or vitreous cells will be frozen to establish a tissue library of uveitis.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Patients of either sex will be admitted to this study. All patients should have a previous history of uveitis. The patient must have lenticular or vitreal opacities which are significantly impairing their vision and for which surgical removal of the opacity has a reasonable chance of improving the vision. Patients should have vision of 20/80 or worse. Patients may have any of the following syndromes: anterior uveitis, including HLA-B27-associated iritis and juvenile rheumatoid arthritis, ocular sarcoid, intermediate uveitis and pars planitis, birdshot retinochoroidopathy, Behcet's disease, Vogt-Koyanagi-Harada's syndrome, sympathic ophthalmia and idiopathic posterior uveitis.
Total Enrollment: 150
Location and Contact Information:
National Eye Institute (NEI)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 870104; 87-EI-0104
Study Start Date: July 6, 1987
Record last reviewed: September 11, 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001224
Other Inflammation Studies:
1. The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated with Juvenile Rheumatoid Arthritis
2. Vascular Endothelial Growth Factor (VEGF) in Uveitis
3. Daclizumab to Treat Non-Infectious Sight-Threatening Uveitis
4. TNRF:Fc to Treat Eye Inflammation in Juvenile Rheumatoid Arthritis
5. Daclizumab Injections to Treat Non-infectious Sight-threatening Uveitis
Related Studies:
Other Inflammation Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Analysis of Eye Tissue
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