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An Open Parallel Study to Determine the Optimum Dosing Schedule for AS-101 in AIDS/ARC Patients Clinical Trials Information presented on Clinical Trials Search isn't intended to be a substitute for proven healthcare advice, trips or treatment using a real physician. We are not docs. Always confer with your mD on An Open Parallel Study to Determine the Optimum Dosing Schedule for AS-101 in AIDS/ARC Patients conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. An Open Parallel Study to Determine the Optimum Dosing Schedule for AS-101 in AIDS/ARC Patients Clinical research trials and An Open Parallel Study to Determine the Optimum Dosing Schedule for AS-101 in AIDS/ARC Patients medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually measure the effectiveness of new drugs. The intention of the studies / projects is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector corporations to detect remedies for all forms of circumstances, like An Open Parallel Study to Determine the Optimum Dosing Schedule for AS-101 in AIDS/ARC Patients. An Open Parallel Study to Determine the Optimum Dosing Schedule for AS-101 in AIDS/ARC Patients Clinical Trials and other clinical trials allow for volunteers to undergo healthcare treatment options before they are available to the masses. Most times the participants receive treatment for free, and every now and again they are paid for their time. Occasionally there is a cost for a An Open Parallel Study to Determine the Optimum Dosing Schedule for AS-101 in AIDS/ARC Patients clinical trial. Subjects typically recieve the finest healthcare available for their An Open Parallel Study to Determine the Optimum Dosing Schedule for AS-101 in AIDS/ARC Patients condition. Hazards are a reality, nonetheless, and might include more or frequent mD trips, health risks (potentially life-endangering), and/or the treatment being ineffective. Trials are federally regulated with stern guidelines to protect clinical trials subjects.

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An Open Parallel Study to Determine the Optimum Dosing Schedule for AS-101 in AIDS/ARC Patients



An Open Parallel Study to Determine the Optimum Dosing Schedule for AS-101 in AIDS/ARC Patients

For Condition: HIV Infections
Status: Completed
Sponsor(s): Wyeth-Ayerst Research ,
Synopsis: To compare AS-101 dosing schedules (once a week; 3 times a week; 5 times a week; or 5 times per week on alternate weeks) on the effect on clinical immunology and virus burden in AIDS or AIDS related complex (ARC) patients.
Details:
Eligibility:
Study Type:
  Interventional, Treatment, Open Label
Minimum Age/Maximum Age: 18 Years/60 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Concurrent Medication: Allowed: - Standard therapy for infections. - Acyclovir. - Ganciclovir. - Allowed only with permission of Wyeth-Ayerst medical monitor: - Zidovudine (AZT). - Immunomodulators. - Specific therapy for malignancies (including Kaposi's sarcoma). Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: - Evidence of severe liver dysfunction (serum albumin < 3 g/dl, SGOT or SGPT > 5 x upper limit of normal, prothrombin time > 15 seconds), or gastrointestinal, renal, respiratory, endocrine, hematologic, cardiovascular system abnormalities or psychiatric disorder other than abnormalities secondary to AIDS or AIDS related complex (ARC). - Evidence of AIDS-related central nervous system involvement. - Disseminated Kaposi's sarcoma. Concurrent Medication: Excluded without permission of Wyeth-Ayerst medical monitor: - Zidovudine (AZT). - Immunomodulators. - Specific therapy for malignancies (including Kaposi's sarcoma). Patients with the following are excluded: - Evidence of major system abnormalities other than abnormalities secondary to AIDS or AIDS related complex. - Concomitant conditions as specified in Patient Exclusion Co-existing Conditions. - Unlikely or unable to comply with the requirements of the protocol. Prior Medication: Excluded within 4 weeks of study entry: - Systemic antiviral agents. - Immunosuppressive agents. - Immune stimulators such as BCG vaccine, isoprinosine, or other immunomodulators. Patients must: - Have a diagnosis of AIDS or AIDS related complex (ARC). - Demonstrate intolerance or refusal to take zidovudine (AZT). - Provide written informed consent.
Total Enrollment: 

Location and Contact Information:

Univ of Arizona / Health Science Ctr
Tucson,  Arizona,  85724
United States
 


Additional Information:
Study ID Numbers:
  045B;  753A-103-US
Study Start Date: 
Record last reviewed: December 1990
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002266

Other Hiv Infections Studies:
1. Tuberculosis in HIV Infected Patients in Uganda

2. A Double-Blind, Randomized, Dose Response Study of Three Doses of Delavirdine Mesylate (U-90152S) in Combination with Zidovudine (ZDV) versus ZDV alone in HIV-1 Infected Individuals with CD4 Counts of 200-500mm3

3. A Multicenter Phase II Double-Blind Exploratory Study to Evaluate Differences Among Various Zidovudine/Didanosine Regimens on Quantitative Measures of Viral Burden in Relatively Early HIV-1 Infection

4. The Use of Bacteriophage phi X174 to Assess the Immune Competence of HIV-Infected Patients In Vivo

5. Using Drug Levels in the Blood to Guide Therapy in HIV Infected Patients Taking a Protease Inhibitor

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An Open Parallel Study to Determine the Optimum Dosing Schedule for AS-101 in AIDS/ARC Patients

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