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Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated with Streptococcal Infections Clinical Trials Facts presented on Clinical Trials Search isn't designed to be a substitute for proven healthcare advice, calls or treatment by using a genuine medical doctor. We aren't mDs. Always confer with your doctor on Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated with Streptococcal Infections conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated with Streptococcal Infections Clinical research trials and Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated with Streptococcal Infections healthcare trials occur in a lot of of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectivity of new does drugs. The role of the studies / undertakings is to solve specific human healthcare questions. Clinical trials are a popular way for doctors, government agencies, and private sector companies to find treatments for all kinds of conditions, including Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated with Streptococcal Infections. Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated with Streptococcal Infections Clinical Trials and other clinical trials allow for volunteers to access health treatment choices before they are available to the general public. Many times the test subjects get treatment for without cost, and sometimes they are compensated for their time. Occasionally there is a cost for a Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated with Streptococcal Infections clinical trial. Test subjects typically receive the most effective healthcare possible for their Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated with Streptococcal Infections condition. Risks are a reality, nonetheless, and could include extra or frequent dr. calls, health hazards (perhaps life-jeopardizing), and/or the treatment being ineffective. Trials are federally regulated with rigid guidelines to protect clinical trials subjects.
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Home > "A" Clinical Trials Conditions > Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated with Streptococcal Infections  Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated with Streptococcal Infections
Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated with Streptococcal Infections
For Condition: Autoimmune Disease,Mental Disorder,Obsessive Compulsive Disorder,Streptococcal Infection,Tic Disorder
Status: Completed
Sponsor(s): National Institute of Mental Health (NIMH) ,
Synopsis: Bacteria carry substances on their surface called antigens. When antigens come into contact with the right kinds of cells in the body an immune reaction is caused. This reaction is often the symptoms of sickness that a patient feels. In order for the body to fight off the attack of antigens, it creates substances called antibodies. Antibodies counter the action of antigens and make the bacteria harmless. However, the immune system must learn how to make the right antibodies for the right antigens. Sometimes the body creates antibodies that confuse normal tissues as foreign and attack them. This is called an autoimmune reaction and sometimes occurs when the body is exposed to certain bacteria. One bacteria known for causing autoimmune reactions is Group A beta-hemolytic Streptococcus (GABHS). This bacteria often causes throat infections commonly known as "strep throat". Some researchers believe that the autoimmune reaction associated with strep throat infections may cause neuropsychiatric disorders, like obsessive-compulsive disorder and/or tic disorder in children. As a result, each time a child with one of these disorders experiences an infection with GABHS his/her symptoms can reoccur or worsen. Researchers believe that by giving patients a certain antibiotic, they can prevent GABHS infection and thus prevent the return of symptoms. This study is designed to test the effectiveness of the antibiotc Amoxicillin for the treatment of Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections (PANDAS). Patients will receive Amoxicillin for six weeks and placebos "inactive sugar pills" for six weeks in order to see if the medication is truly working. Effectiveness of the treatment will be based on the presence or absence of symptoms. If at the end of the study Amoxicillin is proven to be effective treatment for PANDAS patients may be offered the opportunity to continue taking the medication for an additional six months.
Details: An increasing body of evidence suggests that Group A beta-Hemolytic Streptococcal throat infections (GABHS) may trigger the onset of obsessive-compulsive disorder (OCD) and/or tic disorder in certain vulnerable children via an autoimmune process. In this subgroup of children with childhood-onset OCD and tic disorders, preliminary data suggest some children have a rapid response to amoxicillin. After only 24 to 48 hours of treatment, they have a dramatic reduction in OC symptoms and tics. To date, we have observed this phenomenon in at least 5 children, each of whom relapsed when the amoxicillin was stopped. These observations raise a number of questions, including whether or not amoxicillin has a direct central nervous system (CNS) effect or an indirect effect through perturbations of the immune system (e.g., cytokine shifts). The purpose of this study is to determine if amoxicillin is an effective treatment for PANDAS, as well as examining possible mechanisms of this effect. We propose to do this with a 3-month double-blind placebo-controlled crossover trial of amoxicillin treatment with a randomized A-B-A-B design. Outcome measures will be blinded ratings of tic severity, standardized measures of psychopathology, and immunologic assays (such as type I and type II cytokine levels).
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Subjects with presence of OCD and/or tic disorder: Must meet lifetime diagnostic criteria (DSM III or DSM IV) for obsessive compulsive disorder or a tic disorder. Pediatric onset: Symptoms of the disorder first become evident between 3 years of age and the beginning of puberty, as is generally true for rheumatic fever. Episodic course of symptom severity: Clinical course is characterized by the abrupt onset of symptoms or by dramatic symptom exacerbations. Episodic course is characterized by waxing and waning or symptom severity with greater than +20 percent fluctuation from baseline. Association with GABHS infection: Symptom onset or exacerbations must be temporally related to group A B-Hemolytic Streptococcal infections (GABHS), i.e., associated with positive throat culture and/or elevated anti-GABHS antibody titers. Association with neurological abnormalities: During symptom exacerbations, patients will have an abnormal neurological examination, such as motoric hyperactivity and adventitious movements (i.e., choreiform movements or tics). Subjects must report history of improvement in their tics and/or OCD when treated with amoxicillin. No subjects who meet criteria for Autism. No subjects who have neurologic disorders other than tics/TS. No subjects who have and IQ less than 80. No subjects who have a serious concurrent or chronic medical illness. No subjects who have a history of penicillin or amoxicillin allergy. No subjects with history of noncompliance with medical procedures.
Total Enrollment: 30
Location and Contact Information:
National Institute of Mental Health (NIMH)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 970145; 97-M-0145
Study Start Date: July 14, 1997
Record last reviewed: August 31, 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001658
Other Autoimmune Disease Studies:
1. I-123 Brain Studies of Serotonin Metabolism in Psychiatric Patients and Normal Volunteers
2. Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated with Streptococcal Infections
3. Neuropsychiatric Evaluation of Healthy Volunteers and Adults with Schizophrenia
4. Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers
5. Test of A Model of Representational Knowledge Stored in the Human Prefrontal Cortex
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Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated with Streptococcal Infections
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