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Home > "A" Clinical Trials Conditions > AIT-082 Phase 1B Study  AIT-082 Phase 1B Study
AIT-082 Phase 1B Study
For Condition: Memory Disorders
Status: Completed
Sponsor(s): National Institute on Aging (NIA) ,
Synopsis: AIT-082 is a novel small molecule that crosses the blood-brain barrier to enhance nerve function by increasing levels of neurotrophic growth factors and encouraging nerve sprouting in the brain. Preclinical studies in animals have shown that AIT-082 improves memory in aged animals and in animals with neurological deficits. This study was a double-blind placebo-controlled safety study that was designed to study whether AIT-082 may delay age-related mental decline. Eight healthy older volunteers at two clinical sites were given single, weekly, rising doses of AIT-082 or placebo for 5 weeks; were tested for side effects and absorption; and underwent a battery of neuropsychological memory tests, including word and number recall tests.
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: not applicable
Total Enrollment:
Location and Contact Information:
Overall Study Official:
MichaelGrundman, Principal Investigator, University of California, San Diego
Indiana University Alzheimer's Center
Indianapolis, Indiana, 46202
United States
University of Michigan
Ann Arbor, Michigan, 48109-0322
United States
University of California, San Diego
San Diego, California, 92093-0949
United States
Washington University
St. Louis, Missouri, 63110
United States
Additional Information:
Study ID Numbers: IA0008; 3U01AG10483-08S2
Study Start Date:
Record last reviewed: August 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00000180
Other Memory Disorders Studies:
1. Anti-Inflammatory Treatment for Age-Associated Memory Impairment: A Double-Blind Placebo-Controlled Trial
2. Alzheimer's Disease Prevention Trial
3. AIT-082 Phase 1B Study
4. Preventing Cognitive Decline with Alternative Therapies
5. Prevention of cognitive decline in Alzheimer's disease by ingested interferon alpha
Related Studies:
Other Memory Disorders Clinical Trials
Other California Clinical Trials
Other San Diego Clinical Trials
AIT-082 Phase 1B Study
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