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Home > "A" Clinical Trials Conditions > Aging and Cellular Mechanism for Insulin Action after Exercise Training  Aging and Cellular Mechanism for Insulin Action after Exercise Training
Aging and Cellular Mechanism for Insulin Action after Exercise Training
For Condition: Diabetes Mellitus
Status: Recruiting
Sponsor(s): Department of Veterans Affairs Medical Research Service ,
Synopsis: This study will determine whether the metabolic and cellular mechanisms contributing to improved insulin action after aerobic or resistive exercise are different in older, obese, insulin resistant veterans. The hypothesis is that regular exercise, whether aerobic or resistive, will improve whole body insulin action, but the nature and magnitude of changes in skeletal muscle will differ between the two types of exercise.
Details: Veterans will be of comparable body composition and age, and randomly assigned to either aerobic or resistive exercise. They will be instructed in a weight maintenance diet prior to beginning the exercise program, and maintain this diet throughout the study. Metabolic testing will be performed at baseline and after 6 months of exercise training. Testing will include measurement of body composition (anthropometry, dual-energy Xray absorptiometry, computed tomograph scan), maximal oxygen consumption, and muscle strength, glucose tolerance (oral glucose tolerance test), insulin sensitivity (euglycemic-hyperinsulinemic clamp), and muscle biopsies to examine skeletal muscle metabolic characteristics (fiber type distribution, capillary density, oxidative and glycolytic enzyme activities, and levels of key proteins important in insulin signaling and glucose transport). Data will be analyzed using analysis of variance to determine differences between the two exercise groups, and multiple regression analysis to determine the primary adaptations that are associated with the improvements in whole body insulin action.
Eligibility:
Study Type: Interventional, Treatment, Randomized, Uncontrolled, Single Group Assignment, Efficacy Study
Minimum Age/Maximum Age: 50 Years/80 Years
Genders: Both
Protocol Entry Criteria: Males between 50 years and 80 years Overweight Non-smoker Sedentary (no regular exercise for one year)
Total Enrollment:
Location and Contact Information:
Overall Study Official:
AndrewGoldberg, ,
VA Maryland Health Care System *Recruiting*
Baltimore, Maryland, 21201
United States
Recruiting Cynthia Ferrara 410-605-7000
Additional Information:
Study ID Numbers: AGCG-001-99S;
Study Start Date: October 1999
Record last reviewed: June 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00018239
Other Diabetes Mellitus Studies:
1. Effect of AC2993 with or without Immunosuppression on Beta Cell Function in Patients with Type I Diabetes
2. Bypass Angioplasty Revascularization Investigation in Type 2 Diabetics (BARI 2D)
3. Nurses' Health Study
4. Tolerability of Three Local Anesthetic Formulations in Conjunction with NGX-4010 for the Treatment of Neuropathic Pain
5. DPP Outcome Study
Related Studies:
Other Diabetes Mellitus Clinical Trials
Other Maryland Clinical Trials
Other Baltimore Clinical Trials
Aging and Cellular Mechanism for Insulin Action after Exercise Training
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