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Home > "A" Clinical Trials Conditions > Acute Withdrawal from Smoked Cocaine - 9  Acute Withdrawal from Smoked Cocaine - 9
Acute Withdrawal from Smoked Cocaine - 9
For Condition: Cocaine-Related Disorders,Substance Withdrawal Syndrome,Substance-Related Disorders
Status: Completed
Sponsor(s): National Institute on Drug Abuse (NIDA) , University of Minnesota
Synopsis: To develop an experimental paradigm to examine acute withdrawal symptoms from cocaine.
Details: Although there are clearly identifiable withdrawal syndromes following cessation of a number of abused drugs such as alcohol and heroin, it is unclear whether a withdrawal syndrome follows the cessation of crack cocaine. A laboratory model of withdrawal from smoked (crack) cocaine would provide a safe and systematic method of testing the efficacy of behavioral or pharmacological treatments for withdrawal symptoms following cocaine smoking cessation. Therefore, this study investigated acute behavioral, subjective, and physiological withdrawal symptomatology for 6 hrs following 7 deliveries of 2 dose sized (0.07 vs. 0.4 mg/kg) of smoked cocaine. The behavioral measure was performance on a computerized reaction time task, subjective measures included participant and observer ratings of mood and withdrawal symptomatology, and physiological measures comprised heart rate and blood pressure. It was hypothesized that signs and symptoms of withdrawal from smoked cocaine would be greater following the 0.4 mg/kg dose size, compared to the 0.07 mg/kg dose size.
Eligibility:
Study Type: Interventional, Treatment, Double-Blind, Uncontrolled
Minimum Age/Maximum Age: 21 Years/45 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: M/F ages 21-45 with a history of smoked cocaine use at least twice a week for the past six months, including 0.5 g of cocaine in a 24hr period on at least one occasion. In good health as evidenced by physical exam and complete blood count, chest X-ray and electrolyte and liver function tests, with a normal resting 12-lead electrocardiograph (ECG) and blood pressure of less than 140/90 mmHg. Using an acceptable method of birth control. Having a urine toxicology screen positive for cocaine metabolites. Exclusion Criteria: Any DSM-IV Axis I disorder other than cocaine abuse or dependence, or dependence or daily use of psychoactive drugs other than nicotine or caffeine. A history of violence and/or currently on probation, parole or awaiting trial. Pregnant as determined by serum pregnancy screen, lactating or having delivered a child in the past 12 months. Seropositive tests for the human immunodeficiency virus (HIV) or hepatitis B. History of seizure disorder.
Total Enrollment: 0
Location and Contact Information:
Overall Study Official:
DorothyHatsukami, Principal Investigator, University of Minnesota
University of Minnesota
Minneapolis, Minnesota, 55455
United States
Additional Information:
Study ID Numbers: NIDA-09259-9; P50-09259-9
Study Start Date: April 1996
Record last reviewed: April 1996
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00000292
Other Substance Withdrawal Syndrome Studies:
1. Integrated Intervention for Substances Abusers with Depressive Disorders
2. Substance Dependent Teens - Impact of Treating Depression Study 1 - 1
3. Novel Medications for Opiate Detoxification - 4
4. Multimodal Treatment Study of Children with Attention Deficit and Hyperactivity Disorder (ADHD)
5. Cold Water Immersion Modulates Reinforcing Effects of Nitrous Oxide - 2
Related Studies:
Other Substance Withdrawal Syndrome Clinical Trials
Other Minnesota Clinical Trials
Other Minneapolis Clinical Trials
Acute Withdrawal from Smoked Cocaine - 9
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