|
Acupuncture in Cardiovascular Disease Clinical Trials Information presented on Clinical Trials Search is not designed to be a substitute for proven healthcare advice, travels to or treatment by using a genuine medical doctor. We are not physicians. Always confer with your doctor on Acupuncture in Cardiovascular Disease conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Acupuncture in Cardiovascular Disease Clinical research trials and Acupuncture in Cardiovascular Disease healthcare trials take place in many of cities across the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectiveness of new drugs. The function of the studies / undertakings is to answer specific human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector companies to find treatments for all forms of conditions, including Acupuncture in Cardiovascular Disease. Acupuncture in Cardiovascular Disease Clinical Trials and other clinical trials allow for volunteers to access medical treatment alternatives before they are available to the masses. Many times the test subjects undergo treatment for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a Acupuncture in Cardiovascular Disease clinical trial. Test subjects oftentimes recieve the best healthcare possible for their Acupuncture in Cardiovascular Disease condition. Hazards are a reality, nonetheless, and might include additional or frequent doctor trips, healthcare hazards (perhaps life-jeopardizing), and/or the treatment being ineffective. Trials are federally regulated with rigid guidelines to protect clinical trials subjects.
|
|
|
|
|
|
|
Home > "A" Clinical Trials Conditions > Acupuncture in Cardiovascular Disease  Acupuncture in Cardiovascular Disease
Acupuncture in Cardiovascular Disease
For Condition: Congestive Heart Failure
Status: Recruiting
Sponsor(s): National Center for Complementary and Alternative Medicine (NCCAM) ,
Synopsis: The purpose of this study is to determine if acupuncture decreases adrenaline levels in heart failure, thereby potentially improving survival and quality of life.
Details: Acupuncture is used to lower blood pressure in patients with hypertension, and to relieve angina in patients with coronary artery disease. While the biological mechanisms of acupuncture analgesia have been studied intensely in animals and humans, the biological mechanisms for modulation of the cardiovascular system in humans remain largely unexplored. Acupuncture at traditional acupoints, and at nonacupoints, decreases the blood pressure response during mental stress in normal humans. This depressor effect cannot be fully explained by a decline in muscle sympathetic nerve activity (MSNA). Further, in humans with heart failure (HF) in whom MSNA is elevated, we have preliminary data that acupuncture significantly decreases the MSNA response during mental stress. The following hypotheses will be tested: 1) acupuncture, performed at traditional acupoints and non-acupoints in normal humans, stimulates skeletal muscle afferent neurons causing a release of endogenous opioids, which oppose sympathetic excitation and vasoconstriction in visceral vascular beds, such as the kidney; 2) in humans with HF in whom MSNA is elevated and renal vasoconstriction is the rule, acupuncture utilizes similar mechanisms as in normal humans to produce exaggerated inhibition of MSNA and reflex renal vasoconstriction. Positron emission tomography and microneurography will be utilized to answer the following questions in normal humans and patients with heart failure: 1. Is acupuncture attenuation of BP during mental stress mediated by a decrease in renal vasoconstriction? 2. Is acupuncture sympathoinhibitory? 3. Is acupuncture modulation of the autonomic nervous system mediated by muscle afferents? 4. Is acupuncture modulation of the autonomic nervous system mediated by activation of endogenous opioids? Understanding the mechanisms of acupuncture modulation of the autonomic nervous system in humans may help clarify its role as a therapeutic modality in cardiovascular diseases, such as heart failure.
Eligibility:
Study Type: Interventional, Treatment, Randomized, Single Blind, Active Control, Parallel Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: 21 Years/65 Years
Genders: Both
Protocol Entry Criteria: - Chronic congestive heart failure class II-III - No unstable angina - No myocardial infarction within 3 months - No peripheral neuropathy
Total Enrollment: 200
Location and Contact Information:
Overall Study Official:
HollyMiddlekauff, Principal Investigator, University of California, Los Angeles
UCLA School of Medicine *Recruiting*
Los Angeles, California, 90095-1679
United States
Recruiting
Additional Information:
Study ID Numbers: 1 R21 AT00671-01;
Study Start Date: July 2001
Record last reviewed: May 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00032422
Other Congestive Heart Failure Studies:
1. Oxypurinol compared with Placebo for Class III-IV NYHA Congestive Heart Failure
2. Acupuncture in Cardiovascular Disease
3. African-American Heart Failure Trial
4. Rosiglitazone to Treat Patients with Heart Failure and Glucose Intolerance or Type II Diabetes
5. MYOHEARTâ„¢ (Myogenesis Heart Efficiency and Regeneration Trial)
Related Studies:
Other Congestive Heart Failure Clinical Trials
Other California Clinical Trials
Other Los Angeles Clinical Trials
Acupuncture in Cardiovascular Disease
|
|
|
|
|
|
|
|
