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Home > "A" Clinical Trials Conditions > Acupuncture and Hypertension  Acupuncture and Hypertension
Acupuncture and Hypertension
For Condition: Hypertension
Status: Completed
Sponsor(s): National Center for Complementary and Alternative Medicine (NCCAM) ,
Synopsis: Although traditional Chinese medicine advocates the use of acupuncture not only to induce analgesia but also to treat essential hypertension, acupuncture's postulated antihypertensive efficacy in humans has not been subjected to rigorous Western scientific testing. Before advocating acupuncture as an effective complementary/alternative medicine strategy for essential hypertension, it is necessary to demonstrate that the beneficial effects of acupuncture are scientifically robust, long-lasting, and explicable in terms of modern scientific mechanisms. In spontaneously hypertensive rats, acupuncture-like electrical stimulation of thinly myelinated (Group III) somatic afferents activates central endorphin (naloxone-sensitive) pathways that elicit long-lasting decreases in sympathetic nerve activity (SNA) and blood pressure. The ability to record SNA with microelectrodes in conscious humans provides a new opportunity to test this novel mechanistic hypothesis in patients undergoing electroacupuncture, a modification of the ancient technique that provides a quantifiable and reproducible stimulus to human skeletal muscle afferents. Using a randomized, double-blind placebo-controlled design, we will test the following major hypotheses: Electroacupuncture produces a long-lasting reduction in SNA, thereby providing a safe and effective complementary treatment of human hypertension. Given the enormous interest in acupuncture by our lay public, but the paucity of Western scientific data about its efficacy in cardiovascular disorders, our studies in normotensive and hypertensive humans should provide a conceptual framework for deciding whether to accept or reject the large body of Chinese (and Russian) literature advocating acupuncture as a safe and effective treatment of essential hypertension and other cardiovascular disorders (such as heart failure, and myocardial ischemia).
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control
Minimum Age/Maximum Age: 18 Years/65 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Patients with normal blood pressures or blood pressures over 120/80 up to 165/105
Total Enrollment:
Location and Contact Information:
UT Southwestern
Dallas, Texas, 75390
United States
Additional Information:
Study ID Numbers: 1 R01 AT00129-02;
Study Start Date:
Record last reviewed: October 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00010478
Other Hypertension Studies:
1. Epidemiology of Idiopathic Dilated Cardiomyopathy (Washington, DC Dilated Cardiomyopathy Study)
2. Genomewide Search for Loci Underlying Metabolic Syndrome
3. Sleep Apnea in a Non-Clinical Population
4. The SILVER Study: Systolic Hypertension Interaction with Left Ventricular Remodeling
5. Improving Hypertension Care for Inner City Minorities
Related Studies:
Other Hypertension Clinical Trials
Other Texas Clinical Trials
Other Dallas Clinical Trials
Acupuncture and Hypertension
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