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ABT-378/Ritonavir and Efavirenz in HIV-Infected Patients Who Have Taken More Than One Protease Inhibitor in the Past



ABT-378/Ritonavir and Efavirenz in HIV-Infected Patients Who Have Taken More Than One Protease Inhibitor in the Past

For Condition: HIV Infections
Status: Completed
Sponsor(s): ViRx ,
Synopsis: The purpose of this study is to see if ABT-378/ritonavir plus efavirenz is safe and effective in lowering the amount of HIV in the blood of patients who have been treated with more than 1 protease inhibitor (PI).
Details: All patients take ABT-378/ritonavir and efavirenz; there are no placebos in this study. Patients take study medications for 48 weeks, during which time there will be 15 study visits. There is a possibility of a study extension after 48 weeks.
Eligibility:
Study Type:
  Interventional, Treatment, Open Label, Safety Study
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Patients may be eligible for this study if they: - Are HIV-positive. - Have a viral load (level of HIV in the blood) of at least 1,000 copies/ml. - Have been receiving stable (no changes) anti-HIV treatment that includes at least 1 PI for at least 8 weeks prior to study entry. - Have received more than 1 PI for at least 12 weeks each at some time in the past. Exclusion Criteria Patients will not be eligible for this study if they: - Have had any active opportunistic (AIDS-related) infections within the past 30 days. - Have ever received nonnucleoside reverse transcriptase inhibitors (NNRTIs), such as delavirdine, nevirapine, or efavirenz. - Have received certain medications. - Are pregnant or breast-feeding. - Abuse alcohol or drugs.
Total Enrollment: 

Location and Contact Information:

ViRx Inc
San Francisco,  California,  94103
United States
 


Additional Information:
Study ID Numbers:
  285E;  M98-957
Study Start Date: 
Record last reviewed: August 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004582

Other Hiv Infections Studies:
1. Immune restoration by lipoic acid in AIDS

2. A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection in HIV-Infected Persons

3. A Study to Evaluate the Effects of Anti-HIV Drugs in HIV-Positive Patients Who Also Have Hepatitis C Infection

4. A Study of Trimetrexate in the Treatment of Pneumocystis carinii Pneumonia (PCP) in Patients with AIDS Not Previously Treated for PCP

5. Phase II trial of an anti-HIV-1 gene transfer product

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