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Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens Clinical Trials Information presented on Clinical Trials Search isn't designed to be a substitute for certified healthcare advice, travels to or professional assistance using a genuine medical doctor. We are not physicians. Always confer with your dr. about Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens Clinical research trials and Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens medical trials happen in hundreds of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually measure the effectualness of new drugs. The intention of the studies / undertakings is to solve certain human healthcare questions. Clinical trials are a popular manner for mDs, government agencies, and private sector companies to locate treatments for all forms of circumstances, such as Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens. Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens Clinical Trials and other clinical trials allow for volunteers to undergo medical treatment choices before they are available to the general public. Some times the human subjects get treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens clinical trial. Participants frequently get the best healthcare available for their Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens condition. Risks are a reality, nonetheless, and can include extra or frequent physician trips, medical risks (possibly life-jeopardising), and/or the treatment being ineffective. Trials are federally governed with exacting guidelines to protect clinical trials subjects.
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Home > "A" Clinical Trials Conditions > Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens  Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens
Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens
For Condition: Aniridia,Eye Abnormality,Ocular Hypertension,Open Angle Glaucoma
Status: Completed
Sponsor(s): National Eye Institute (NEI) ,
Synopsis: This study will investigate congenital or developmental eye abnormalities that affect the iris, cornea and lens, and are usually accompanied by elevated pressure within the eye. These disorders can cause vision loss, and the increased eye pressure can lead to glaucoma, a condition that may also cause loss of eyesight. Patients with eye anterior chamber eye disease, such as Axenfeld's syndrome, Rieger's anomaly, Peter's anomaly, iridocorneal endothelial syndrome, megalocornea, ocular hypertension, and others, are eligible for this study. Participants will have a medical examination, family history, and comprehensive eye examination. Tests and procedures may include photographs of the cornea, iris, and the structure through which fluid that normally circulates behind the cornea drains out of the eye. Some patients may undergo indentation tonography to measure how easily this fluid drains. In this procedure, the patient lies on an examination table and both eyes are numbed with eye drops. A small instrument (tonometer) is placed on the surface of one eye, and with the other eye, the patient looks at an overhead light. Other tests may include photographs of the back of the eye and ultrasound imaging of the structures of the eye. A blood sample may be drawn to study the genetic disorder responsible for the disease. Patients will have follow-up examinations every 6 months for the duration of the study. Medical or surgical therapy will be recommended, as appropriate, for patients who develop elevated eye pressure or vision loss.
Details: This study will concentrate on abnormalities of the anterior chamber with or without elevated intraocular pressure. The purpose of the study will be to determine if there is a common pathogenesis shared by these conditions. A natural history study of 40 individuals with these diseases will utilize clinical measurements and photographs for documentation of this hypothesis. In addition, surgical specimens, when available, will be studied.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: The eye conditions to be studied include Axenfeld's syndrome, Rieger's anomaly, Peter's anomaly, (all with or without glaucoma), Iridocorneal Endothelial syndrome, Aniridia, Pigment Dispersion syndrome, Megalocornea and other conditions with clinical abnormalities of the anterior chamber. Patients will not be included in the study if they do not fit the morphologic characteristics of the disease in question or if the patient's general medical condition or other related factors make it impossible for him or her to continue participation in the study.
Total Enrollment: 100
Location and Contact Information:
National Eye Institute (NEI)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 770119; 77-EI-0119
Study Start Date: July 1, 1977
Record last reviewed: August 19, 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001161
Other Ocular Hypertension Studies:
1. Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens
Related Studies:
Other Ocular Hypertension Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens
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