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A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for qualified medical advice, visits or professional assistance by using a real mD. We are not docs. Always confer with your physician about A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts Clinical research trials and A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts health trials occur in many of cities throughout the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectivity of new does drugs. The intent of the studies / undertakings is to resolve particular human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to detect remedies for all sorts of conditions, including A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts. A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts Clinical Trials and other clinical trials permit volunteers to obtain healthcare treatment alternatives before they are available to the masses. Most times the participants undergo professional assistance for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts clinical trial. Test subjects typically receive the most expert healthcare available for their A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts condition. Dangers are a reality, however, and may include more or frequent mD visits, healthcare dangers (perhaps life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
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Home > "A" Clinical Trials Conditions > A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts
A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts
For Condition: Pneumonia, Pneumocystis carinii,HIV Infections
Status: Completed
Sponsor(s): National Institute of Allergy and Infectious Diseases (NIAID) ,
Synopsis: The purpose of this study is to see how often Pneumocystis carinii pneumonia (PCP) occurs in HIV-positive patients who have stopped taking medications that help prevent PCP. The risk of developing PCP may be decreased when an HIV-positive patient's CD4 cell counts (cells of the immune system which fight infection) are more than 200 cells/mm3. This study looks at whether it is acceptable to stop PCP prevention treatment in these patients.
Details: The risk of developing PCP may be decreased with treatment-induced recovery of CD4 counts to > 200 cells/mm3. Few data exist to confirm or negate the continued necessity of PCP prophylaxis for such patients. This study will assess the effects of discontinuing therapy. Subjects are asked to discontinue PCP prophylaxis if antiretroviral therapy has resulted in a sustained CD4 increase greater than 200 cells/mm3 on two measurements at least 12 weeks apart. They will be evaluated for symptoms and CD4 counts every 8 weeks as well as plasma for HIV-RNA every 16 weeks for 18 months. Subjects whose CD4 count falls to less than 150 cells/mm3 or between 150 and 200 cells/mm3 will have the CD4 count re-evaluated immediately or within 4 weeks. If the second CD4 count is less than 200 cells/mm3 for either case, conventional PCP prophylaxis will be resumed and the subject will be followed on study. Subjects will be followed during study by physical exams and laboratory tests at Weeks 4, 8, and every 8 weeks thereafter.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: 13 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria You may be eligible for this study if you: - Are HIV-positive. - Have had 1 CD4 cell count of less than 100 cells/mm3 and have never had PCP, or have had at least 2 CD4 cell counts over 200 cells/mm3 and have had PCP within 6 months prior to study entry. - Have received PCP prevention medication within 3 months of study entry. - Are at least 13 years old (need consent if under 18). - Are taking anti-HIV (antiretroviral) medication at study entry. Exclusion Criteria You will not be eligible for this study if you: - Have active PCP or symptoms of PCP within 2 weeks of study entry. - Have a fever lasting more than 2 weeks. - Have oral candidiasis (thrush).
Total Enrollment: 250
Location and Contact Information:
Overall Study Official:
SusanKoletar, Study Chair,
Johns Hopkins Hosp
Baltimore, Maryland, 21287
United States
Santa Clara Valley Med Ctr / AIDS Community Rsch Consortium
San Jose, California, 951282699
United States
Queens Med Ctr
Honolulu, Hawaii, 96816
United States
Univ of Washington
Seattle, Washington, 98104
United States
Beth Israel Deaconess - West Campus
Boston, Massachusetts, 02215
United States
Boston Med Ctr
Boston, Massachusetts, 02118
United States
Univ of Minnesota
Minneapolis, Minnesota, 55455
United States
Univ of Cincinnati
Cincinnati, Ohio, 452670405
United States
Duke Univ Med Ctr
Durham, North Carolina, 27710
United States
Chelsea Ctr
New York City, New York, 10021
United States
SUNY / Erie County Med Ctr at Buffalo
Buffalo, New York, 14215
United States
Howard Univ
Washington D.C., District of Columbia, 20059
United States
Northwestern Univ Med School
Chicago, Illinois, 60611
United States
Kaiser Permanente LAMC
Los Angeles, California, 90027
United States
Indiana Univ Hosp
Indianapolis, Indiana, 462025250
United States
Univ of Pennsylvania at Philadelphia
Philadelphia, Pennsylvania, 19104
United States
Univ of Pittsburgh Med Ctr
Pittsburgh, Pennsylvania, 15213
United States
Philadelphia Veterans Administration Med Ctr
Philadelphia, Pennsylvania, 19104
United States
Beth Israel Med Ctr
New York City, New York, 10003
United States
Univ of Colorado Health Sciences Ctr
Denver, Colorado, 80262
United States
Univ of Miami School of Medicine
Miami, Florida, 331361013
United States
Kaiser Foundation Hosp
Harbor City, California, 90710
United States
Marin County Specialty Clinic
San Rafael, California, 94903
United States
San Mateo AIDS Program / Stanford Univ
Stanford, California, 943055107
United States
St Louis Regional Hosp / St Louis Regional Med Ctr
St. Louis, Missouri, 63112
United States
Univ of Nebraska Med Ctr
Omaha, Nebraska, 681985130
United States
Cornell Univ Med Ctr
New York City, New York, 10021
United States
Emory Univ
Atlanta, Georgia, 30308
United States
Mount Sinai Med Ctr
New York City, New York, 10029
United States
Division of Inf Diseases/ Indiana Univ Hosp
Indianapolis, Indiana, 46202
United States
Univ of Rochester Medical Center
Rochester, New York, 14642
United States
Harvard (Massachusetts Gen Hosp)
Boston, Massachusetts, 02114
United States
Univ of Puerto Rico
San Juan, , 009365067
Puerto Rico
MetroHealth Med Ctr
Cleveland, Ohio, 441091998
United States
Willow Clinic
Menlo Park, California, 94025
United States
Case Western Reserve Univ
Cleveland, Ohio, 44106
United States
Univ of Kentucky Lexington
Cincinnati, Ohio, 45267
United States
Rush Presbyterian - Saint Luke's Med Ctr
Chicago, Illinois, 60612
United States
St Mary's Hosp (Univ of Rochester/Infectious Diseases)
Rochester, New York, 14642
United States
San Francisco AIDS Clinic / San Francisco Gen Hosp
San Francisco, California, 941102859
United States
Methodist Hosp of Indiana / Life Care Clinic
Indianapolis, Indiana, 46202
United States
Cook County Hosp
Chicago, Illinois, 60612
United States
Univ of Hawaii / Leahi Hosp
Honolulu, Hawaii, 96816
United States
Stanford Univ Med Ctr
Stanford, California, 943055107
United States
Univ of Southern California / LA County USC Med Ctr
Los Angeles, California, 900331079
United States
Univ of Alabama at Birmingham
Birmingham, Alabama, 35294
United States
Univ of California / San Diego Treatment Ctr
San Diego, California, 921036325
United States
San Francisco Gen Hosp
San Francisco, California, 941102859
United States
Univ of North Carolina
Chapel Hill, North Carolina, 275997215
United States
Bellevue Hosp / New York Univ Med Ctr
New York City, New York, 10016
United States
Louis A Weiss Memorial Hosp
Chicago, Illinois, 60640
United States
Julio Arroyo
West Columbia, South Carolina, 29169
United States
Beth Israel Deaconess Med Ctr
Boston, Massachusetts, 02215
United States
Ohio State Univ Hosp Clinic
Columbus, Ohio, 432101228
United States
Additional Information:
Study ID Numbers: ACTG 888;
Study Start Date:
Record last reviewed: February 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00000908
Other Hiv Infections Studies:
1. Aerosols in the Treatment of Asymptomatic Pneumocystis Pneumonia: A Pilot Study Assessing the Effectiveness of Aerosolized Pentamidine as Treatment of Subclinical Pneumocystis Infection in Patients With No Clinical Symptoms
2. The Safety and Effectiveness of Pentamidine in the Prevention of Pneumocystis carinii Pneumonia (PCP) in Patients with AIDS Who Have Had PCP Before
3. A Study of Trimetrexate Plus Leucovorin in Children with Pneumocystis Carinii Pneumonia
4. A Randomized, Comparative, Prospective Study of Daily Trimethoprim / Sulfamethoxazole (TMS) and Thrice-Weekly TMS for Prophylaxis Against PCP in HIV-Infected Patients
5. The Safety and Effectiveness of Methylprednisolone in the Treatment of Pneumocystis carinii Pneumonia (PCP) in Children with AIDS
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A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts
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