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A study to evaluate the effects of YM872 on stroke lesion volume in acute stroke patients Clinical Trials Information presented on Clinical Trials Search is not intended to be a substitute for qualified health advice, trips or treatment by using a genuine doctor. We aren't doctors. Always consult your mD on A study to evaluate the effects of YM872 on stroke lesion volume in acute stroke patients conditions. Clinical Trials Search.org is a site committed to listing clinical research studies in human subjects. A study to evaluate the effects of YM872 on stroke lesion volume in acute stroke patients Clinical research trials and A study to evaluate the effects of YM872 on stroke lesion volume in acute stroke patients health trials take place in a lot of of cities across the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally measure the potency of new drugs. The aim of the studies / projects is to answer specific human medical questions. Clinical trials are a popular manner for physicians, government agencies, and private sector corporations to discover remedies for all kinds of circumstances, like A study to evaluate the effects of YM872 on stroke lesion volume in acute stroke patients. A study to evaluate the effects of YM872 on stroke lesion volume in acute stroke patients Clinical Trials and other clinical trials allow for volunteers to have health treatment alternatives before they are available to the general public. Many times the test subjects obtain treatment for without cost, and occasionally they are paid for their time. Sometimes there is a cost for a A study to evaluate the effects of YM872 on stroke lesion volume in acute stroke patients clinical trial. Subjects oftentimes recieve the most effective healthcare possible for their A study to evaluate the effects of YM872 on stroke lesion volume in acute stroke patients condition. Hazards are a reality, however, and could include additional or frequent doctor visits, healthcare dangers (perhaps life-threatening), and/or the treatment being ineffective. Trials are federally governed with exacting guidelines to protect clinical trials subjects.
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Home > "A" Clinical Trials Conditions > A study to evaluate the effects of YM872 on stroke lesion volume in acute stroke patients  A study to evaluate the effects of YM872 on stroke lesion volume in acute stroke patients
A study to evaluate the effects of YM872 on stroke lesion volume in acute stroke patients
For Condition: Cerebrovascular Accident
Status: Completed
Sponsor(s): Yamanouchi Pharma America ,
Synopsis: This study will investigate the effects of a potential neuroprotectant compound, YM872, in the treatment of acute ischemic stroke. The study will determine if a 24-hour infusion of YM872, given within 6 hours of stroke onset, reduces the ischemic lesion volume as measured by MRI at 28 days after the infusion is given. The clinical effects of YM872 will also be determined by neurological function and disability scores at follow up visits through Day 90 of the study.
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Patients who have suffered an acute ischemic stroke and can be evaluated and treatment initiated within 6 hours after the onset of symptoms (Onset is defined as the time that which the patient was last seen in a normal state, or bedtime for unwitnessed strokes occurring during the night). - Patients who have a three dimensionally measurable lesion compatible with an acute ischemic stroke measured using MRI. - Patients who have a National Institutes of Health Stroke Scale (NIHSS) score of at least 7 but not more than 23 and who are conscious. - Patients who are able to provide written informed consent or have consent provided by a legally authorized representative. - Patients who are at least 18 years of age. - Other criteria as specified in the study protocol Exclusion Criteria: - Patients who have received alteplase (t-PA) for the current stroke episode. It is assumed that all patients who are eligible will receive treatment with t-PA. - Patients who have disability and functional limitations prior to the current stroke episode (e.g. deficit resulting from a prior stroke). - Patients who have brain hemorrhage. - Patients who have stroke of the brainstem or cerebellum. - Patients who cannot be evaluated using MRI due to the presence of a pacemaker, claustrophobia, need for sedation, etc. - Patients who have renal (kidney) disease or insufficiency. - Patients who have active epilepsy or convulsions during the current stroke episode. - Patients who are IV drug users or are inebriated. - Patients who have a history of drug-related anaphylaxis. - Patients who have taken sedatives, anticonvulsants, or any medication with sedating effects in the 10 days prior study enrollment. - Patients who have taken more than 1.3 g of aspirin per day in the 2 days prior to enrollment. - Patients who have a known vitamin hypersensitivity. - Other exclusion criteria as specified by the study protocol.
Total Enrollment:
Location and Contact Information:
St. Elizabeth Health Center
Youngstown, Ohio,
United States
Wayne State University
Detroit, Michigan,
United States
Sacred Heart Medical Center
Spokane, Washington,
United States
Theda Clark Medical Center
Neenah, Wisconsin,
United States
University of Arizona
Tucson, Arizona,
United States
Department of Neurology Klinikum
Minden, ,
Germany
University of South Alabama Stroke Center
Mobile, Alabama,
United States
Neurology Associates, Inc. (St. Mary's Hospital)
Richmond, Virginia,
United States
Universitätskrankenhaus Hamburg-Eppendorf Klinik für Neurologie
Hamburg-Eppendorf, ,
Germany
University of Miami (Jackson Memorial Hospital)
Miami, Florida,
United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts,
United States
Universitätsklinik Allgemeines
Wien, ,
Austria
Neurology Group of Bergen County (Valley Hospital)
Ridgewood, New Jersey,
United States
Neurologische Klinik Knappschafts - krankenhause
Recklinghausen, ,
Germany
Sunninghill Hospital
Sunninghill,, ,
South Africa
Santa Monica UCLA Medical Center
Santa Monica, California,
United States
Chattanooga Neurology Associates (Erlanger Hospital)
Chattanooga, Tennessee,
United States
Dr.-H.-Schmidt-Kliniken Ludwig-Erhar
Wiesbaden, ,
Germany
Field Neurosciences Institute (St. Mary's Hospital)
Saginaw, Michigan,
United States
Stevens Memorial Hospital
Edmonds, Washington,
United States
All-Trials Clinical Research, LLC (Rowan Regional Medical Center)
Winston Salem, North Carolina,
United States
Long Island Jewish Medical Center
New Hyde Park, New York,
United States
New England Medical Center
Boston, Massachusetts,
United States
Ellis Hospital
Schenectady, New York,
United States
Grossmont Hospital
La Mesa, California,
United States
JFK Medical Center
Edison, New Jersey,
United States
Friedrich-Schiller-University
Jena, ,
Germany
Phoenix Neurology Associates (Good Samaritan Hospital)
Phoenix, Arizona,
United States
Florida Neurovascular Institute
Tampa, Florida,
United States
Holmes Regional Medical Center
Melbourne, Florida,
United States
St. Patrick's Hospital & Health Sciences Center
Missoula, Montana,
United States
Hershey Medical Center
Hershey, Pennsylvania,
United States
University of Essen
ESSEN, ,
Germany
DNA Research (Dekalb Medical Center)
Decatur, Georgia,
United States
Bloemfontein Medi-Clinic
Bloemfontein, ,
South Africa
Vanderbilt University Medical Center
Nashville, Tennessee,
United States
Bridgeport Hospital
Bridgeport, Connecticut,
United States
Neurologische Klinik Klinikum Rechts der Isar der TU Munchen
Munchen, ,
Germany
Dienst Neurologie UZ Gasthuisberg
Leuven, ,
Belgium
Good Samaritan Hospital
San Jose, California,
United States
University of Alberta Hospital
Edmonton, Alberta,
Canada
Toronto Western Hospital
Toronto, Ontario,
Canada
Universitatklinikum Leipzig
Leipzig, ,
Germany
St. Thomas Hospital
Nashville, Tennessee,
United States
Louisville Neuroscience Research Center
Louisville, Kentucky,
United States
Advanced Neurology Specialists (Benefis Healthcare Hospital)
Great Falls, Montana,
United States
Michigan State University
East Lansing, Michigan,
United States
Providence St. Peter Hospital
Olympia, Washington,
United States
St. Augustine's Hospital
Durban, ,
South Africa
Pietermaritzburg Medi-Clinic
PIETERMARITZBURG, ,
South Africa
Chattanooga Neurology Associates (Memorial Hospital)
Chattanooga, Tennessee,
United States
Universitatklinikum Homburg, Neurologie Klinik und Poliklinik
HOMBURG / SAAR, ,
Germany
University of New Mexico Hospital
Albuquerque, New Mexico,
United States
Hopital Erasme
Brussels, ,
Belgium
Neurologische Universitätsklinik, Albert-Ludwigs-University
Freiburg, ,
Germany
Washoe Comprehensive Stroke Center
Reno, Nevada,
United States
Medical College of Ohio
Toledo, Ohio,
United States
Buffalo General Hospital
Buffalo, New York,
United States
Providence St. Joseph's Medical Center
Burbank, California,
United States
William Beaumont Hospital
Royal Oak, Michigan,
United States
Royal Jubilee Hospital
Victoria, British Columbia,
Canada
Muelmed Hospital
Arcadia, ,
South Africa
Metrohealth Medical Center
Cleveland, Ohio,
United States
Service de Neurologie, Cliniques Universitaires St.-Luc
BRUXELLES, ,
Belgium
Universitätsklinikum Aachen, Neurologische Klinik
Aachen, ,
Germany
Cullicchia Neurology Clinic, LLP
Marrero, Louisiana,
United States
University of Kentucky
Lexington, Kentucky,
United States
University of Texas (Houston Medical Center)
Houston, Texas,
United States
North Shore University Hospital
Manhasset, New York,
United States
Little Company of Mary Medical Centre
Pretoria, ,
South Africa
Bethesda Memorial Hospital
Boynton Beach, Florida,
United States
OSF St. Francis Medical Center
Peoria, Illinois,
United States
Stony Brook Hospital
Stony Brook, New York,
United States
Albany Medical Center
Albany, New York,
United States
Universität zu Köln klinik und poliklinik fur neurology
Koln, ,
Germany
John Muir Medical Center
Walnut Creek, California,
United States
UCLA Emergency Medical Center
Los Angeles, California,
United States
University of Pittsburgh Medical Center Stroke Institute
Pittsburgh, Pennsylvania,
United States
Sandton Medi-Clinic
Johannesburg, ,
South Africa
Groote Schuur Hospital
Cape Town, ,
South Africa
Riverside Methodist Hospital
Columbus, Ohio,
United States
Johns Hopkins Medical Institute
Baltimore, Maryland,
United States
St. Luke's Medical Center
Milwaukee, Wisconsin,
United States
St. Luke's Hospital
New York City, New York,
United States
Parkview Hospital
Ft. Wayne, Indiana,
United States
Universitätsklinik Mainz
Mainz, ,
Germany
VA Medical Center
Albuquerque, New Mexico,
United States
Vergelegen Medi-Clinic
Somerset West, ,
South Africa
Virginia Beach General Hospital
Virginia Beach, Virginia,
United States
Additional Information:
Study ID Numbers: 872-CL-003;
Study Start Date: December 2000
Record last reviewed: February 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00044070
Other Cerebrovascular Accident Studies:
1. Improving Motor Learning in Stroke Patients
2. Compare the effects of amiodarone, sotalol, and placebo in maintaining sinus rhythm in patients with atrial fibrillation converted to sinus rhythm
3. Evaluation of Treated and Untreated Stroke
4. The ARIC and Neurocognitive Longitudinal Study
5. Preventing Post-Stroke Depression
Related Studies:
Other Cerebrovascular Accident Clinical Trials
Other Tennessee Clinical Trials
Other Chattanooga Clinical Trials
A study to evaluate the effects of YM872 on stroke lesion volume in acute stroke patients
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