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A Study of Thymopentin Effects on HIV-1 Infectivity of Blood Mononuclear Cells and Semen in HIV Infected Patients



A Study of Thymopentin Effects on HIV-1 Infectivity of Blood Mononuclear Cells and Semen in HIV Infected Patients

For Condition: HIV Infections
Status: Completed
Sponsor(s): Immunobiology Research Institute ,
Synopsis: Examine the ability of Timunox (thymopentin) to reduce the amount and/or frequency of virus isolation. Examine the ability of thymopentin to stimulate the immune system and alter the clinical findings in patients infected with HIV who do not yet have AIDS.
Details:
Eligibility:
Study Type:  Interventional, Treatment, Double-Blind
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Concurrent Medication: Allowed: - Aerosolized pentamidine. Patients must have the following: - Seropositive for HIV-1 (ELISA assay) confirmed by Western blot. - HIV-1 p24 antigen must be detected in supernatant fluids from co-cultures of patients' PBMC on two separate occasions. - Voluntarily sign consent. - Patients with HIV "wasting syndrome" are allowed. Prior Medication: Allowed: - Aerosolized pentamidine. Exclusion Criteria Co-existing Condition: Patients with the following are excluded: - AIDS as defined by the CDC. - Significant hepatic disease. - Thrombocytopenia. - Hypersensitivity to thymopentin. - Hemophilia A or B or other hematologic disorders requiring current or previous administration of blood products. - Abnormal chest x-ray (indicative of active disease (opportunistic infection)) within 30 days prior to study entry. Patients with the following are excluded: - AIDS as defined by the CDC. - Significant hepatic disease. - Thrombocytopenia. - Hypersensitivity to thymopentin. - Hemophilia A or B or other hematologic disorders requiring current or previous administration of blood products. - Abnormal chest x-ray (indicative of active disease (opportunistic infection)) within 30 days prior to study entry. Prior Medication: Excluded within 30 days of study entry: - Immunomodulatory or experimental therapy. - Excluded within 90 days of study entry: - Zidovudine (AZT). Intravenous drug abuse.
Total Enrollment: 

Location and Contact Information:

Immunobiology Research Institute
Annandale,  New Jersey,  088010999
United States
 


Additional Information:
Study ID Numbers:  015D;  H87-75
Study Start Date: 
Record last reviewed: August 1989
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002050

Other Hiv Infections Studies:
1. Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS-Related Primary Central Nervous System Lymphoma

2. Safety and Effectiveness of Anti-HIV Vaccines in HIV-Negative Adults

3. Cidofovir as a Treatment for Herpes Simplex in Patients with AIDS

4. Treatment of Patients With Human Immunodeficiency Virus (HIV)-Related Chronic Diarrhea With Saccharomyces boulardii or Placebo: A Double Blind Trial

5. Comparison of Three Anti-HIV Drug Combinations in HIV-Infected Patients with No Symptoms of the Disease

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