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A study of Rituxan in the treatment of polyneuropathies associated with serum IgM autoantibodies Clinical Trials Information presented on Clinical Trials Search is not designed to be a substitute for proven healthcare advice, travels to or treatment by using a genuine medical doctor. We are not physicians. Always confer with your doctor on A study of Rituxan in the treatment of polyneuropathies associated with serum IgM autoantibodies conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. A study of Rituxan in the treatment of polyneuropathies associated with serum IgM autoantibodies Clinical research trials and A study of Rituxan in the treatment of polyneuropathies associated with serum IgM autoantibodies healthcare trials take place in many of cities across the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectiveness of new drugs. The function of the studies / undertakings is to answer specific human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector companies to find treatments for all forms of conditions, including A study of Rituxan in the treatment of polyneuropathies associated with serum IgM autoantibodies. A study of Rituxan in the treatment of polyneuropathies associated with serum IgM autoantibodies Clinical Trials and other clinical trials allow for volunteers to access medical treatment alternatives before they are available to the masses. Many times the test subjects undergo treatment for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a A study of Rituxan in the treatment of polyneuropathies associated with serum IgM autoantibodies clinical trial. Test subjects oftentimes recieve the best healthcare possible for their A study of Rituxan in the treatment of polyneuropathies associated with serum IgM autoantibodies condition. Hazards are a reality, nonetheless, and might include additional or frequent doctor trips, healthcare hazards (perhaps life-jeopardizing), and/or the treatment being ineffective. Trials are federally regulated with rigid guidelines to protect clinical trials subjects.

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A study of Rituxan in the treatment of polyneuropathies associated with serum IgM autoantibodies



A study of Rituxan in the treatment of polyneuropathies associated with serum IgM autoantibodies

For Condition: Peripheral Neuropathy
Status: No longer recruiting
Sponsor(s): National Center for Research Resources (NCRR) , Genentech
Synopsis: Peripheral neuropathies cause weakness and sensory loss that can produce severe disability. Some neuropathies are immune-mediated and associated with antibodies. It has been postulated that Rituxan treatment may reduce the level of antibody production limiting the loss of muscle strength and hence improve activities of daily living. The purpose of this open-label study (all participants get Rituxan and not placebo) is to determine the safety and effectiveness of Rituxan in the treatment of polyneuropathies associated with serum IgM autoantibodies in those who have already been treated with one course of Rituxan. Subjects will be treated on the in-patient Clinical Research Center with Rituxan for two treatments one week a part and then individual treatments every 10 weeks for one year. The effectiveness of Rituxan will be followed by looking for increases in muscle strength and decreases in the serum IgM autoantibodies.
Details:
Eligibility:
Study Type:
  Interventional, Treatment, Open Label
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Diagnosis of characteristic peripheral neuropathy by appropriate history, physical examination, nerve conduction findings and serum autoantibodies. - Serum anti-GM1 on anti-MAG antibodies present at high titers in serum, continued by testing in the neuromuscular clinical laboratory at Washington University.
Total Enrollment: 

Location and Contact Information:


Additional Information:
Study ID Numbers:
  NCRR-M01RR00036-0690;  M01RR00036
Study Start Date: 
Record last reviewed: July 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00006072

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