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A Study of Isoprinosine in Patients with Severe AIDS



A Study of Isoprinosine in Patients with Severe AIDS

For Condition: HIV Infections
Status: Completed
Sponsor(s): Newport Pharmaceuticals International ,
Synopsis: To evaluate the effect of Isoprinosine in patients diagnosed as having AIDS relative to: Laboratory (immunologic defects): o Comparison of total helper and suppressor T-cell numbers among the groups. o Comparison of changes in natural killer cell activity. o Comparison of other laboratory findings among the groups. Clinical changes: o Comparison of the frequency of opportunistic infections among the groups. o Comparison of the frequency of the development of AIDS-related malignancies. o Comparison of other clinical manifestations relative to severity and time of onset.
Details:
Eligibility:
Study Type:
  Interventional, Treatment, Double-Blind
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Exclusion Criteria Co-existing Condition: Patients with a history of gout, urolithiasis, nephrolithiasis, renal dysfunction, and severe gastric ulcer are excluded. Concurrent Medication: Excluded: - Steroids. - Cytotoxic immunosuppressive agents. - Radiotherapy. The following are excluded: - Critically ill patients. - Patients receiving steroids, cytotoxic immunosuppressive agents, radiotherapy. - Patients who have received any other immunotherapy. - Patients with a history of gout, urolithiasis, nephrolithiasis, renal dysfunction, and severe gastric ulcer. Prior Medication: Excluded: - Any other immunotherapy. Patients with severe AIDS and specified laboratory immunologic defects.
Total Enrollment: 

Location and Contact Information:

Newport Pharmaceuticals International Inc
Laguna Hills,  California,  92656
United States
 


Additional Information:
Study ID Numbers:
  008F;  ISO-141-USA
Study Start Date: 
Record last reviewed: June 1989
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002295

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5. A Randomized Phase II Efficacy, Activity and Safety Study of GLQ223 Alone and in Combination with Zidovudine in Symptomatic HIV-Infected Patients Without Prior Treatment with GLQ223 or Trichosanthin

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