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Home > "A" Clinical Trials Conditions > A Study of Isoprinosine in Patients with Lymph Node Disease  A Study of Isoprinosine in Patients with Lymph Node Disease
A Study of Isoprinosine in Patients with Lymph Node Disease
For Condition: Lymphatic Disease,HIV Infections
Status: Completed
Sponsor(s): Newport Pharmaceuticals International ,
Synopsis: The objectives of this study are to determine the effects of isoprinosine in patients diagnosed as having unexplained generalized lymphadenopathy. Variables to be examined will include: Signs and symptoms: o Lymphadenopathy. o Fever. o Weight loss. o Occurrence of opportunistic infections. Cell-mediated immune system parameters: o T-helper cell (OKT4) numbers and proportions. o T-suppressor cell (OKT8) numbers and proportions. o Natural killer (NK) cell activity. o Lymphocyte blastogenic response to phytohemagglutinin (PHA). o Lymphocyte blastogenic response to pokeweed mitogen (PWM). o Immunoglobulin (IgG, IgA, IgM, IgE, IgD) profile. o Circulating immune complexes. Infections characteristically associated with AIDS, such as Candida albicans, Pneumocystis carinii pneumonia, Cytomegalovirus, Herpes simplex, Cryptococcus, Histoplasma, Toxoplasma, Cryptosporidium, Mycobacterium avium- intracellulare, Legionella, and Isospora. Safety parameters: o Blood chemistry including serum uric acid (PurposeA-12). o Complete blood count (CBC). o Platelet count.
Details:
Eligibility:
Study Type: Interventional, Treatment, Double-Blind
Minimum Age/Maximum Age: 18 Years/
Genders: Male
Protocol Entry Criteria: Exclusion Criteria Co-existing Condition: Patients with a history of gout, uric acid urolithiasis, uric acid nephrolithiasis, renal dysfunction, or gastric ulceration are excluded. Concurrent Medication: Excluded: - Systemic corticosteroids. - Cytotoxic immunosuppressive agents. - Radiotherapy. Critically ill patients or those with CDC-defined AIDS are excluded. Prior Medication: Excluded within 1 month of study entry: - Immunotherapy. Patients with persistent generalized lymphadenopathy (PGL).
Total Enrollment:
Location and Contact Information:
Newport Pharmaceuticals International Inc
Laguna Hills, California, 92656
United States
Additional Information:
Study ID Numbers: 008A; ISO-103-USA
Study Start Date:
Record last reviewed: June 1989
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002297
Other Hiv Infections Studies:
1. Study of Autoimmune Lymphoproliferative Syndrome (ALPS)
2. The Safety and Effectiveness of Isoprinosine in Patients with Weakened Immune Systems and Lymph Node Disease
3. A Multi-Center Randomized Double-Blind Placebo-Controlled Study To Investigate the Effect of Isoprinosine in Immunodepressed Patients With Uncomplicated Generalized Lymphadenopathy
4. Pyrimethamine to Treat Autoimmune Lymphoproliferative Syndrome
5. A Study of Isoprinosine in Patients with Lymph Node Disease
Related Studies:
Other HIV Infections Clinical Trials
Other California Clinical Trials
Other Laguna Hills Clinical Trials
A Study of Isoprinosine in Patients with Lymph Node Disease
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