|
A Study of HIV-Disease Development in Aging Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified medical advice, calls or professional assistance using a genuine dr.. We aren't physicians. Always confer with your dr. on A Study of HIV-Disease Development in Aging conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. A Study of HIV-Disease Development in Aging Clinical research trials and A Study of HIV-Disease Development in Aging medical trials happen in hundreds of localities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new does drugs. The intent of the studies / undertakings is to answer particular human health questions. Clinical trials are a popular manner for physicians, government agencies, and private sector corporations to find cures for all kinds of circumstances, like A Study of HIV-Disease Development in Aging. A Study of HIV-Disease Development in Aging Clinical Trials and other clinical trials permit volunteers to acquire healthcare treatment options before they are available to the general public. Some times the subjects acquire professional assistance for free, and sometimes they are paid for their time. Sometimes there is a cost for a A Study of HIV-Disease Development in Aging clinical trial. Participants frequently obtain the most expert healthcare available for their A Study of HIV-Disease Development in Aging condition. Dangers are a reality, nevertheless, and can include more or frequent doctor calls, health risks (potentially life-jeopardizing), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.
|
|
|
|
|
|
|
Home > "A" Clinical Trials Conditions > A Study of HIV-Disease Development in Aging  A Study of HIV-Disease Development in Aging
A Study of HIV-Disease Development in Aging
For Condition: HIV Infections
Status: No longer recruiting
Sponsor(s): National Institute of Allergy and Infectious Diseases (NIAID) ,
Synopsis: The purpose of this study is to better understand the relationship between age and HIV disease progression. This study will explore the possible relationship between age and HIV disease progression. Older age is an important risk factor for faster disease development, but older people may respond better to combination drug therapy. This relationship needs to be understood better.
Details: Older age is an important risk factor for accelerated HIV-disease progression. However, the virologic response to highly active antiretroviral therapy (HAART) may be superior in older persons. A better understanding of the immunologic, virologic, and behavioral mechanisms that underlie these age-related differences may help to elucidate critical immune responses that are necessary to control the progression of HIV-disease. Patients are grouped according to age. Group A consists of patients between the ages of 13 and 30 years. Group B consists of patients age 45 years or older. All patients receive open-label lopinavir/ritonavir (LPV/RTV) plus emtricitabine (FTC) plus stavudine (d4T) for 96 [AS PER AMENDMENT 06/04/02: 192] weeks. Study visits occur at pre-entry, entry, and Weeks 4, 8, 12, 16, and 24 then every 12 weeks thereafter through Week 96 [AS PER AMENDMENT 06/04/02: Week 192]. Clinical assessments, safety laboratory tests, CD4 cell count monitoring, lymphocyte phenotyping, and HIV-1 RNA determinations are performed routinely. Blood samples are stored for further immunology and virology studies. Patients may volunteer to participate in virology substudy A5020s and either immunology substudy A5016s or A5017s [AS PER AMENDMENT 06/04/02: Substudy A5017s has been eliminated.]
Eligibility:
Study Type: Interventional, Treatment, Efficacy Study
Minimum Age/Maximum Age: 13 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Patients may be eligible for this study if they: - Are HIV-positive. - Are between 13 and 30 years old (need consent of parent or guardian if under 18), or are more than 44 years of age. - Have a viral load of more than 2000 copies/ml within 60 days of study entry. - Have a CD4 cell count of less than 600 cells/mm3 within 60 days of study entry. (This reflects a change in the CD4 cell count requirement.) - Agree to use effective methods of birth control (such as condoms) during and for 12 weeks after the study. Exclusion Criteria Patients will not be eligible for this study if they: - Are pregnant or breast-feeding. - Have an AIDS-related cancer (except Kaposi's sarcoma) requiring chemotherapy. - Have hepatitis within 30 days of study entry. - Have diarrhea (more than 3 liquid stools/day for at least 14 days) within 30 days of study entry. - Are receiving chemotherapy or radiation treatment. - Have taken antiretroviral drugs for more than 14 days. - Have received an HIV vaccine within 30 days of study. - Have a serious illness or infection within 14 days of the study. - Have other serious conditions that might interfere with study participation. - Have taken or plan to take certain other drugs that might affect the study results.
Total Enrollment: 90
Location and Contact Information:
Overall Study Official:
RobertKalayjian, Study Chair,
Case Western Reserve Univ
Cleveland, Ohio, 44106
United States
Bellevue Hosp / New York Univ Med Ctr
New York City, New York, 10016
United States
Mount Sinai Med Ctr
New York City, New York, 10029
United States
Ohio State Univ Hosp Clinic
Columbus, Ohio, 432101228
United States
Denver Dept of Health and Hosps
Denver, Colorado, 80262
United States
Brigham and Women's Hosp
Boston, Massachusetts, 02215
United States
Marin County Specialty Clinic
San Rafael, California, 94903
United States
Philadelphia Veterans Administration Med Ctr
Philadelphia, Pennsylvania, 19104
United States
Univ of Pennsylvania at Philadelphia
Philadelphia, Pennsylvania, 19104
United States
Univ of Texas Galveston
Galveston, Texas, 775550435
United States
Indiana Univ Hosp
Indianapolis, Indiana, 462025250
United States
Community Health Network Inc
Rochester, New York, 14642
United States
Julio Arroyo
West Columbia, South Carolina, 29169
United States
Johns Hopkins Hosp
Baltimore, Maryland, 21287
United States
Univ of Hawaii
Honolulu, Hawaii, 96816
United States
Rush Presbyterian - Saint Luke's Med Ctr
Chicago, Illinois, 60612
United States
Univ of Southern California / LA County USC Med Ctr
Los Angeles, California, 900331079
United States
Stanford Univ Med Ctr
Stanford, California, 943055107
United States
Santa Clara Valley Med Ctr / AIDS Community Rsch Consortium
San Jose, California, 951282699
United States
Univ of Rochester Medical Center
Rochester, New York, 14642
United States
San Mateo AIDS Program / Stanford Univ
Stanford, California, 943055107
United States
Harvard (Massachusetts Gen Hosp)
Boston, Massachusetts, 02114
United States
State of MD Div of Corrections / Johns Hopkins Univ Hosp
Baltimore, Maryland, 212052196
United States
Univ of Washington
Seattle, Washington, 98104
United States
Univ of Miami School of Medicine
Miami, Florida, 331361013
United States
Univ of Colorado Health Sciences Ctr
Denver, Colorado, 80262
United States
Univ of Puerto Rico
San Juan, , 009365067
Puerto Rico
Northwestern Univ Med School
Chicago, Illinois, 60611
United States
Queens Med Ctr
Honolulu, Hawaii, 96816
United States
MetroHealth Med Ctr
Cleveland, Ohio, 441091998
United States
San Francisco Gen Hosp
San Francisco, California, 941102859
United States
Univ of Minnesota
Minneapolis, Minnesota, 55455
United States
Univ of North Carolina
Chapel Hill, North Carolina, 275997215
United States
Univ of Texas, Southwestern Med Ctr of Dallas
Dallas, Texas, 75390
United States
Miriam Hosp / Brown Univ
Providence, Rhode Island, 02906
United States
Carolinas Med Ctr
Charlotte, North Carolina, 28232
United States
Willow Clinic
Menlo Park, California, 94025
United States
Duke Univ Med Ctr
Durham, North Carolina, 27710
United States
Beth Israel Med Ctr
New York City, New York, 10003
United States
Wishard Hosp
Indianapolis, Indiana, 46202
United States
Methodist Hosp of Indiana / Life Care Clinic
Indianapolis, Indiana, 46202
United States
Boston Med Ctr
Boston, Massachusetts, 02118
United States
Additional Information:
Study ID Numbers: ACTG A5015; Substudy ACTG A5020s,AACTG A5015,Substudy ACTG A5016s
Study Start Date:
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00006144
Other Hiv Infections Studies:
1. The Effects of Illnesses on HIV Levels in the Body
2. A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of 200 mcg of gp120 (CHO) BIOCINE in MF59 Emulsion Versus the Emulsion Control: Three Injections at 0, 1, and 6 Months
3. The Effectiveness of Nelfinavir and Efavirenz, Used Alone or Together, Combined with Other Anti-HIV Drugs in Patients Who Have Taken Anti-HIV Drugs
4. The Effect of Valacyclovir on the Detection of HIV from Genital Herpes Lesions in HIV-Infected Patients
5. A Phase I Trial of Tecogalan sodium ( DS-4152 ) Administered as an Infusion Twice Weekly for 21 Days.
Related Studies:
Other HIV Infections Clinical Trials
Other California Clinical Trials
Other Los Angeles Clinical Trials
A Study of HIV-Disease Development in Aging
|
|
|
|
|
|
|
|
