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Home > "A" Clinical Trials Conditions > A Registry of Tuberculosis Cases in the CPCRA A Registry of Tuberculosis Cases in the CPCRA
A Registry of Tuberculosis Cases in the CPCRA
For Condition: HIV Infections,Tuberculosis
Status: No longer recruiting
Sponsor(s): National Institute of Allergy and Infectious Diseases (NIAID) ,
Synopsis: PRIMARY: To estimate the proportion of tuberculosis patients in the CPCRA who have drug-resistant tuberculosis (TB) and to describe the patterns of drug resistance. SECONDARY: To compare drug resistance data on the Mycobacterium tuberculosis isolates of HIV-positive patients to those of HIV-negative patients who are being followed in the CPCRA. To assess the relationship of resistance data with geographic, demographic, and HIV and TB risk factor information. Geographic areas and demographic subgroups affected by the TB epidemic appear to be congruent and associated with the concurrent HIV epidemic. The total number of CPCRA patients who will develop, or who have experienced, confirmed TB is unknown. It is critical to determine the depth and breadth of the current problem of drug-resistant TB.
Details: Geographic areas and demographic subgroups affected by the TB epidemic appear to be congruent and associated with the concurrent HIV epidemic. The total number of CPCRA patients who will develop, or who have experienced, confirmed TB is unknown. It is critical to determine the depth and breadth of the current problem of drug-resistant TB. For both retrospective and prospective components of the study, demographic, geographic, HIV and TB risk factor information will be collected on CPCRA patients with confirmed pulmonary or extrapulmonary TB. Mycobacterial culture results will be recorded. Retrospective data will be collected on CPCRA patients with confirmed tuberculosis who have been diagnosed since January 1992 until the time of site registration. Prospective data will be collected on CPCRA patients with confirmed tuberculosis diagnosed during the period of 1 to 2 years following site registration.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Patients must meet the following criteria: - CPCRA patients with confirmed pulmonary or extrapulmonary TB. Confirmed clinical TB requires a positive culture for Mycobacterium tuberculosis. NOTE: - There is no requirement that patients have HIV infection.
Total Enrollment: 500
Location and Contact Information:
Overall Study Official:
FredGordin, Study Chair,
Veterans Administration Med Ctr / Regional AIDS Program
Washington D.C., District of Columbia, 20422
United States
Henry Ford Hosp
Detroit, Michigan, 48202
United States
Addiction Research and Treatment Corp
Brooklyn, New York, 11201
United States
Bronx Lebanon Hosp Ctr
Bronx, New York, 10456
United States
Harlem AIDS Treatment Group / Harlem Hosp Ctr
New York City, New York, 10037
United States
Clinical Directors Network of Region II
New York City, New York, 10011
United States
Louisiana Comm AIDS Rsch Prog / Tulane Univ Med
New Orleans, Louisiana, 70112
United States
Denver CPCRA / Denver Public Hlth
Denver, Colorado, 802044507
United States
Comprehensive AIDS Alliance of Detroit
Detroit, Michigan, 48201
United States
Richmond AIDS Consortium
Richmond, Virginia, 23298
United States
North Jersey Community Research Initiative
Newark, New Jersey, 071032842
United States
AIDS Research Alliance - Chicago
Chicago, Illinois, 60657
United States
Portland Veterans Adm Med Ctr / Rsch & Education Grp
Portland, Oregon, 972109951
United States
Additional Information:
Study ID Numbers: CPCRA 017;
Study Start Date:
Record last reviewed: January 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00000785
Other Hiv Infections Studies:
1. A Study of MKC-442 in Combination with Other Anti-HIV Drugs
2. Valganciclovir in Patients with CMV Retinitis and AIDS Who Cannot Take Drugs by Injection
3. The Effectiveness of HIV RNA Viral Load Testing in Determining Treatment Type in HIV-Infected Patients
4. Safety and Effectiveness of Giving an Anti-HIV Drug Combination of Adefovir Dipivoxil Plus Didanosine Plus Efavirenz Plus Lamivudine Once Daily to HIV-Infected Patients
5. A Pharmacokinetic Study of L-697,661 Alone and in Combination with Zidovudine
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A Registry of Tuberculosis Cases in the CPCRA
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