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Home > "A" Clinical Trials Conditions > A Randomized, Open-Label Study of Alternative Treatment Combinations of Dideoxycytidine (HIVID; ddC) and Zidovudine (AZT) in Patients With HIV Infection

A Randomized, Open-Label Study of Alternative Treatment Combinations of Dideoxycytidine (HIVID; ddC) and Zidovudine (AZT) in Patients With HIV Infection



A Randomized, Open-Label Study of Alternative Treatment Combinations of Dideoxycytidine (HIVID; ddC) and Zidovudine (AZT) in Patients With HIV Infection

For Condition: HIV Infections
Status: Completed
Sponsor(s): Hoffmann-La Roche ,
Synopsis: To investigate the appropriate zalcitabine ( dideoxycytidine; ddC ) dose and zidovudine ( AZT ) schedule for use in combination therapy in patients with HIV infection.
Details: Patients are randomized to one of four treatment arms. ddC is administered at 1 of 2 doses every 8 hours. AZT is administered at 1 of 2 doses (every 4 hours while awake or every 8 hours).
Eligibility:
Study Type:
  Interventional, Treatment, Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Patients must have: - HIV infection. - CD4 count 100 - 500 cells/mm3.
Total Enrollment: 528

Location and Contact Information:

Univ TX Galveston Med Branch
Galveston,  Texas,  775550882
United States
 

SUNY / Health Sciences Ctr at Brooklyn
Brooklyn,  New York,  11203
United States
 

Oregon Health Sciences Univ
Portland,  Oregon,  97201
United States
 

Kaiser Permanente Med Ctr
Los Angeles,  California,  90027
United States
 

St Paul Ramsey Med Ctr / HIV Program Office
St. Paul,  Minnesota,  55101
United States
 

Univ of Kansas School of Medicine
Wichita,  Kansas,  67214
United States
 

New England Med Ctr
Boston,  Massachusetts,  02111
United States
 

Howard Univ
Washington D.C.,  District of Columbia,  20060
United States
 

Miami Veterans Administration Med Ctr
Miami,  Florida,  33125
United States
 

Kaiser Foundation Hosp
Harbor City,  California,  90710
United States
 

Bronx Veterans Affairs Med Ctr
Bronx,  New York,  10468
United States
 

Ohio State Univ Hosp Clinic
Columbus,  Ohio,  432101228
United States
 

UCSF - San Francisco Gen Hosp
San Francisco,  California,  94110
United States
 

Denver Public Health Dept / Disease Control Services
Denver,  Colorado,  80204
United States
 

Saint Luke's - Roosevelt Hosp Ctr
New York City,  New York,  10019
United States
 

Rush Presbyterian - Saint Luke's Med Ctr
Chicago,  Illinois,  60612
United States
 

Dr Brian Buggy
Milwaukee,  Wisconsin,  53215
United States
 

Intergrated Care Ctr
Atlanta,  Georgia,  30327
United States
 

Veterans Administration Med Ctr
Washington D.C.,  District of Columbia,  20422
United States
 

Washington Univ
St. Louis,  Missouri,  63110
United States
 

Univ of New Mexico School of Medicine
Albuquerque,  New Mexico,  87131
United States
 

Univ of Miami School of Medicine
Miami,  Florida,  33136
United States
 

N Texas Ctr for AIDS & Clin Rsch
Dallas,  Texas,  75219
United States
 

Sharp Rees - Stealy Med Group
San Diego,  California,  92101
United States
 


Additional Information:
Study ID Numbers:
  220A;  NV 14257
Study Start Date: 
Record last reviewed: February 1995
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002117

Other Hiv Infections Studies:
1. A Study to Evaluate the Effects of Giving IL-2 Alone to HIV-Positive Patients with CD4 Cell Counts of at Least 350 Cells/mm3 Who Do Not Wish to Receive Anti-HIV Therapy

2. A Study of Ribavirin in the Treatment of Patients with AIDS and AIDS-Related Problems

3. Daily Isoniazid to Prevent Tuberculosis in Infants Born to Mothers with HIV

4. Dideoxycytidine ( Ro 24-2027 ) A Randomized, Open-Label, Comparative Study of Dideoxycytidine ( ddC ) versus Zidovudine ( AZT ) in Patients With AIDS or Advanced ARC Who Have Received Long-Term AZT Therapy.

5. Vitamin A Therapy for Tuberculosis

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A Randomized, Open-Label Study of Alternative Treatment Combinations of Dideoxycytidine (HIVID; ddC) and Zidovudine (AZT) in Patients With HIV Infection

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