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A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination with Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients Clinical Trials Info presented on Clinical Trials Search is not intended to be a substitute for certified medical advice, visits or professional assistance using a real physician. We are not physicians. Always consult your dr. about A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination with Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination with Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients Clinical research trials and A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination with Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients health trials happen in many of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new drugs. The function of the studies / projects is to resolve particular human medical questions. Clinical trials are a popular manner for mDs, government agencies, and private sector corporations to discover remedies for all varieties of circumstances, like A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination with Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients. A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination with Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients Clinical Trials and other clinical trials allow volunteers to obtain healthcare treatment options before they are available to the masses. Some times the participants undergo professional assistance for free of charge, and occasionally they are paid for their time. Sometimes there is a cost for a A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination with Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients clinical trial. Human subjects often get the best healthcare available for their A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination with Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients condition. Dangers are a reality, however, and may include additional or frequent mD visits, healthcare dangers (potentially life-jeopardising), and/or the treatment being ineffectual. Trials are federally governed with rigorous guidelines to protect clinical trials patients.
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Home > "A" Clinical Trials Conditions > A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination with Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients  A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination with Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients
A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination with Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients
For Condition: Mycobacterium avium-intracellulare Infection,HIV Infections
Status: Completed
Sponsor(s): Pfizer ,
Synopsis: To evaluate the efficacy and safety of two different doses of azithromycin in combination with ethambutol for the treatment of patients with Mycobacterium avium complex (MAC) infection, and to determine whether an azithromycin-containing regimen is at least as safe and effective as the same regimen containing clarithromycin..
Details: Patients are randomized to receive azithromycin at one of two doses in combination with ethambutol or clarithromycin in combination with ethambutol for 24 weeks, after which they are evaluated for entry into a maintenance phase of treatment. Clinical, microbiologic, and safety assessments are performed every 3 weeks for the first 12 weeks, then monthly for the remaining 12 weeks.
Eligibility:
Study Type: Interventional, Treatment, Double-Blind, Safety Study
Minimum Age/Maximum Age: 13 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Patients must have: - HIV seropositivity. - Disseminated MAC. - No MAC therapy between time of last positive blood culture draw and study entry (single-agent prophylaxis allowed). - Life expectancy of at least 2 months. - Consent of parent or guardian if below legal age of consent. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: - Known hypersensitivity to macrolide antibiotics (erythromycin, azithromycin, or clarithromycin) or ethambutol. - Inability to take oral medications. - Condition likely to interfere with drug absorption (e.g., gastrectomy, malabsorption syndromes). Concurrent Medication: Excluded: - Another investigational drug started in the week prior to study entry. Prior Medication: Excluded: - MAC therapy between time of last positive blood culture draw and study entry (although single-agent prophylaxis is allowed).
Total Enrollment:
Location and Contact Information:
Dr Milton Estes
Mill Valley, California, 94941
United States
Infectious Disease Med Group / Adult Immunology Clinic
Oakland, California, 94609
United States
Duke Univ Med Ctr
Durham, North Carolina, 27710
United States
Northwestern Univ Med School
Chicago, Illinois, 60611
United States
Bay Area AIDS Consortium
Tampa, Florida, 33609
United States
Oschner Clinic
New Orleans, Louisiana, 70121
United States
Georgetown Univ Med Ctr
Washington D.C., District of Columbia, 20007
United States
Thomas Street Clinic / Baylor College of Medicine
Houston, Texas, 77009
United States
Pfizer Central Research
Groton, Connecticut, 06340
United States
Santa Clara Valley Med Ctr
San Jose, California, 951282699
United States
Kaiser Permanente Med Ctr
San Francisco, California, 94115
United States
East Bay AIDS Ctr
Berkeley, California, 94705
United States
Central Texas Med Foundation
Austin, Texas, 78751
United States
Hampton Roads Med Specialists
Hampton, Virginia, 23666
United States
Univ of Texas Southwestern Med Ctr of Dallas
Dallas, Texas, 75235
United States
Med Service
Miami, Florida, 33125
United States
Dr Neel French / Louis A Weiss Memorial Hosp
Chicago, Illinois, 60640
United States
Dr Robert Wallace
St. Petersburg, Florida, 33713
United States
Dr Gary Brewton
Houston, Texas, 77027
United States
Trinity Lutheran Hosp / Infectious Disease Clinic
Kansas City, Missouri, 64108
United States
Whitman - Walker Clinic
Washington D.C., District of Columbia, 20009
United States
UCI Med Ctr
Orange, California, 92668
United States
West Paces Clinical Research Inc
Atlanta, Georgia, 30327
United States
Austin Infectious Disease Consultants
Austin, Texas, 78705
United States
Additional Information:
Study ID Numbers: 226B; 066-189,189/189B
Study Start Date:
Record last reviewed: July 1998
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002140
Other Mycobacterium Avium-Intracellulare Infection Studies:
1. Effectiveness of Interleukin-2 (IL-2) Plus Anti-HIV Therapy in HIV-Positive Patients
2. T-20 in HIV Patients with Prior Drug Treatment and/or Resistance to Each of the Three Classes of Anti-HIV Drugs
3. A Study of 1592U89 Combined with Other Anti-HIV Drugs in Patients Who Have Taken Anti-HIV Drugs
4. A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection
5. A Study of Zidovudine in HIV-Infected Pregnant Women and Their Children
Related Studies:
Other Mycobacterium avium-intracellulare Infection Clinical Trials
Other Connecticut Clinical Trials
Other Groton Clinical Trials
A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination with Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients
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