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A Cross Sectional Clinical Study of Human Lens Aging and Cataract Formation, in Vivo, Uning Dynamic Light Scattering (DLS) Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified medical advice, calls or professional assistance using a genuine dr.. We aren't physicians. Always confer with your dr. on A Cross Sectional Clinical Study of Human Lens Aging and Cataract Formation, in Vivo, Uning Dynamic Light Scattering (DLS) conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. A Cross Sectional Clinical Study of Human Lens Aging and Cataract Formation, in Vivo, Uning Dynamic Light Scattering (DLS) Clinical research trials and A Cross Sectional Clinical Study of Human Lens Aging and Cataract Formation, in Vivo, Uning Dynamic Light Scattering (DLS) medical trials happen in hundreds of localities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new does drugs. The intent of the studies / undertakings is to answer particular human health questions. Clinical trials are a popular manner for physicians, government agencies, and private sector corporations to find cures for all kinds of circumstances, like A Cross Sectional Clinical Study of Human Lens Aging and Cataract Formation, in Vivo, Uning Dynamic Light Scattering (DLS). A Cross Sectional Clinical Study of Human Lens Aging and Cataract Formation, in Vivo, Uning Dynamic Light Scattering (DLS) Clinical Trials and other clinical trials permit volunteers to acquire healthcare treatment options before they are available to the general public. Some times the subjects acquire professional assistance for free, and sometimes they are paid for their time. Sometimes there is a cost for a A Cross Sectional Clinical Study of Human Lens Aging and Cataract Formation, in Vivo, Uning Dynamic Light Scattering (DLS) clinical trial. Participants frequently obtain the most expert healthcare available for their A Cross Sectional Clinical Study of Human Lens Aging and Cataract Formation, in Vivo, Uning Dynamic Light Scattering (DLS) condition. Dangers are a reality, nevertheless, and can include more or frequent doctor calls, health risks (potentially life-jeopardizing), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.
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Home > "A" Clinical Trials Conditions > A Cross Sectional Clinical Study of Human Lens Aging and Cataract Formation, in Vivo, Uning Dynamic Light Scattering (DLS)  A Cross Sectional Clinical Study of Human Lens Aging and Cataract Formation, in Vivo, Uning Dynamic Light Scattering (DLS)
A Cross Sectional Clinical Study of Human Lens Aging and Cataract Formation, in Vivo, Uning Dynamic Light Scattering (DLS)
For Condition:
Status: Recruiting
Sponsor(s): National Eye Institute (NEI) ,
Synopsis: A new non invasive, in vivo technique to study the molecular changes in the human lens, called Dynamic Light Scattering Device (DLS), has recently been developed. Preliminary studies have shown its potential to detect the earliest changes in cataract, at the stage where anti-cataract treatment would be most effective in reversing, delaying or preventing cataracts. A new miniaturized version of this device has been developed by NASA using lower energy lasers, and under a NASA-NEI Inter Agency Agreement, has been successfully developed into a clinical device at the NEI. We recently conducted pilot studies to evaluate the usefulness and reproducibility of this instrument for quantitating human lens changes, and found good reproducibility. We also derived a useful parameter to use with this new technique, the log mean particle size, derived from particle size distribution data. Preliminary studies have also shown that the NASA-NEI DLS device can be used to detect and monitor molecular changes in early cataract formation as well as in normal aging. We therefore propose to conduct a larger cross sectional clinical study to detect and monitor molecular changes in the lens in early cataract formation and in normal aging.
Details: A new non invasive, in vivo technique to study the molecular changes in the human lens, called Dynamic Light Scattering Device (DLS), has recently been developed. Preliminary studies have shown its potential to detect the earliest changes in cataract, at the stage where anti-cataract treatment would be most effective in reversing, delaying or preventing cataracts. A new miniaturized version of this device has been developed by NASA using lower energy lasers, and under a NASA-NEI Inter Agency Agreement, has been successfully developed into a clinical device at the NEI. We recently conducted pilot studies to evaluate the usefulness and reproducibility of this instrument for quantitating human lens changes, and found good reproducibility. We also derived a useful parameter to use with this new technique, the log mean particle size, derived from particle size distribution data. Preliminary studies have also shown that the NASA-NEI DLS device can be used to detect and monitor molecular changes in early cataract formation as well as in normal aging. We therefore propose to conduct a larger cross sectional clinical study to detect and monitor molecular changes in the lens in early cataract formation and in normal aging.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Patients aged 18-80 years will be admitted to this study. There will be no racial or gender bias in the recruitment. 227 patients with AREDS Clinical Grades 2 or less for nuclear cataract, will be enrolled in the study. 40 patients with AREDS nuclear cataract grade 3 and 4 will also be enrolled. For those patients enrolled from the AREDS population, only one eye will be evaluated for this protocol. The eye to be examined will be defined as follows: If the patient has only one eligible eye, that eye will be examined. If the patient's birth month is an even number, the right eye will be examined; if the patient's birth month is odd, the left eye will be examined. EXCLUSION CRITERIA: Subjects who have tear film disorders, corneal opacities or disorders, uveitis, glaucoma or who have difficulty fixating, will be excluded. Subjects who are thought to be at risk for an adverse reaction to pupil dilation, or have a history of allergic reaction to one of the dilating agents that will be used, will be excluded.
Total Enrollment: 240
Location and Contact Information:
National Eye Institute (NEI) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 040166; 04-EI-0166
Study Start Date: April 22, 2004
Record last reviewed: April 14, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00081991
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A Cross Sectional Clinical Study of Human Lens Aging and Cataract Formation, in Vivo, Uning Dynamic Light Scattering (DLS)
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