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A Comparison of Two Types of Injected Nutritional Supplements in Patients with AIDS and Pneumocystis carinii Pneumonia (PCP)



A Comparison of Two Types of Injected Nutritional Supplements in Patients with AIDS and Pneumocystis carinii Pneumonia (PCP)

For Condition: HIV Infections
Status: Completed
Sponsor(s): Abbott Laboratories ,
Synopsis: The objectives of this study are: To establish whether there is a difference in clinical effectiveness of Liposyn II 20 percent as compared with Liposyn III 2 percent in AIDS patients with Pneumocystis carinii pneumonia (PCP). To compare the effects of the two lipid emulsions on immunologic function in AIDS patients. To compare the effect of the two lipid emulsions on HIV load in AIDS patients as measured by reverse transcriptase (RT) in culture. To determine whether a decrease in HIV infectivity is greater in patients given a parenteral feeding regimen containing Liposyn II 20 percent or Liposyn III 2 percent.
Details:
Eligibility:
Study Type:  Interventional, Treatment
Minimum Age/Maximum Age: 18 Years/60 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Concurrent Medication: Allowed: - All drugs used for the standard treatment of Pneumocystis carinii pneumonia (PCP). - Other drugs for treatment of other AIDS conditions if they have been started more than 3 months prior to study entry. Patients must have: - Diagnosis of AIDS. - Weight loss > 10 percent of premorbid body weight. - First or second episode of acute Pneumocystis carinii pneumonia (PCP). Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: - Do Not Resuscitate (DNR) status. - Biliary stasis. Patients with the following are excluded: - Do Not Resuscitate (DNR) status. - Biliary stasis. Prior Medication: Excluded within 3 months of study entry: - Immunomodulators. - Antiviral new DT
Total Enrollment: 

Location and Contact Information:

East Orange Veterans Administration Med Ctr
East Orange,  New Jersey,  07018
United States
 


Additional Information:
Study ID Numbers:  041B; 
Study Start Date: 
Record last reviewed: May 1990
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002275

Other Hiv Infections Studies:
1. A Phase I Trial of APL 400-003 Vaccine: Safety and Immune Response Evaluations of Multiple Injections at Escalating Doses in Asymptomatic HIV-Infected Patients

2. A Phase I Study of the Combination of Recombinant GM-CSF, AZT, and Chemotherapy (ABV) (Adriamycin, Bleomycin, Vincristine) in AIDS and Kaposi's Sarcoma

3. A Study of Thymopentin Effects on HIV-1 Infectivity of Blood Mononuclear Cells and Semen in HIV Infected Patients

4. A Study to Compare the Use of Fluconazole as Continuous Therapy Versus Periodic Therapy in HIV-Positive Patients with Recurrent Thrush

5. The Effectiveness of Three Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Never Used Anti-HIV Drugs

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Other HIV Infections Clinical Trials
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Other East Orange Clinical Trials

A Comparison of Two Types of Injected Nutritional Supplements in Patients with AIDS and Pneumocystis carinii Pneumonia (PCP)
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