|
A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients with AIDS Clinical Trials Information presented on Clinical Trials Search is not designed to be a substitute for proven healthcare advice, travels to or treatment by using a genuine medical doctor. We are not physicians. Always confer with your doctor on A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients with AIDS conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients with AIDS Clinical research trials and A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients with AIDS healthcare trials take place in many of cities across the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectiveness of new drugs. The function of the studies / undertakings is to answer specific human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector companies to find treatments for all forms of conditions, including A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients with AIDS. A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients with AIDS Clinical Trials and other clinical trials allow for volunteers to access medical treatment alternatives before they are available to the masses. Many times the test subjects undergo treatment for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients with AIDS clinical trial. Test subjects oftentimes recieve the best healthcare possible for their A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients with AIDS condition. Hazards are a reality, nonetheless, and might include additional or frequent doctor trips, healthcare hazards (perhaps life-jeopardizing), and/or the treatment being ineffective. Trials are federally regulated with rigid guidelines to protect clinical trials subjects.
|
|
|
|
|
|
|
Home > "A" Clinical Trials Conditions > A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients with AIDS  A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients with AIDS
A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients with AIDS
For Condition: Candidiasis, Oral,HIV Infections
Status: Completed
Sponsor(s): Pfizer ,
Synopsis: To compare the efficacy, safety, and tolerance of fluconazole single daily capsule for 14 days versus clotrimazole troche 5 x daily for 14 days in the treatment of oropharyngeal candidiasis in patients with AIDS.
Details:
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: 13 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Concurrent Medication: Allowed: - Cimetidine. Exclusion Criteria Co-existing Condition: Patients with the following are excluded: - Known history of intolerance or allergy to imidazoles or triazoles, or the non-azole components of clotrimazole troches (dextrose, cellulose, povidone, magnesium stearate). - Moderate or severe liver disease defined by specified lab values. Concurrent Medication: Excluded pending results of phase I studies to determine whether interaction between fluconazole and these agents occurs: - Barbiturates. - Phenytoin. - Coumarin-type anticoagulants. - Rifampin. - Oral hypoglycemics. - Cyclosporin. Patients with the following are excluded: - Known history of intolerance or allergy to imidazoles or triazoles, or the non-azole components of clotrimazole troches (dextrose, cellulose, povidone, magnesium stearate). - Unable to tolerate oral medication. - Moderate or severe liver disease defined by specified lab values. - Life expectancy < 4 weeks. - Unable or unwilling to be followed at the same center for the conduct of this study. Prior Medication: Excluded within 3 days of study entry: - Other antifungal agents. - Excluded pending results of phase I studies to determine whether interaction between fluconazole and these agents occurs: - Barbiturates. - Phenytoin. - Coumarin-type anticoagulants. - Rifampin. - Oral hypoglycemics. - Cyclosporin. Patients meeting CDC criteria for diagnosis of AIDS, or having serologic or virologic evidence of HIV infection (but without AIDS-defining opportunistic infections as of yet). - Patients who have given informed consent in writing to their participation in the study. - Patients with signs of oropharyngeal candidiasis, i.e., with typical white plaques.
Total Enrollment:
Location and Contact Information:
Buckley Braffman Stern Med Associates
Philadelphia, Pennsylvania, 19107
United States
Washington Univ School of Medicine
St. Louis, Missouri, 63108
United States
Univ Hosp
Boston, Massachusetts, 02118
United States
SUNY / Health Sciences Ctr at Stony Brook
Stony Brook, New York, 117948153
United States
Ohio State Univ Hosp
Columbus, Ohio, 43210
United States
Saint Michael's Med Ctr
Newark, New Jersey, 07102
United States
Infectious Disease Physicians Inc
Annandale, Virginia, 22203
United States
George Washington Univ Med Ctr
Washington D.C., District of Columbia, 20037
United States
Cabrini Med Ctr
New York City, New York, 10003
United States
Dr Robert Larsen
Los Angeles, California, 90033
United States
UCSF Hosp
San Francisco, California, 941430654
United States
Univ TX San Antonio Health Science Ctr
San Antonio, Texas, 78284
United States
Cornell Univ Med Ctr
New York City, New York, 10021
United States
Summitt Med Ctr / San Francisco Gen Hosp
Oakland, California, 94609
United States
Saint Raphael's Hosp
New Haven, Connecticut, 06511
United States
Davies Med Ctr
San Francisco, California, 94114
United States
Johns Hopkins Hosp
Baltimore, Maryland, 21205
United States
Additional Information:
Study ID Numbers: 012M; 056-171
Study Start Date:
Record last reviewed: February 1990
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002282
Other Candidiasis, Oral Studies:
1. A Study to Compare Two Anti-HIV Drug Combinations
2. Safety and Effectiveness of Two Different Formulations of an HIV Vaccine in Infants Born to HIV-Infected Women
3. A Phase I Study of the Safety and Pharmacokinetics of Recombinant Human CD4-Immunoglobulin G (rCD4-IgG) Administered by Intravenous Bolus Injection in Combination With Oral Zidovudine in Patients With AIDS and AIDS-Related Complex
4. A Phase I Clinical Trial To Evaluate the Toxicity, Antiviral and Immunomodulatory Effects of a Range of Doses of Ampligen in HIV-Infected Subjects
5. Study of How Indinavir (an Anti-HIV Drug) and Rifabutin (a Drug Used to Treat MAC, an HIV-Associated Disease) Interact in HIV-Positive and HIV-Negative Adults
Related Studies:
Other Candidiasis, Oral Clinical Trials
Other District of Columbia Clinical Trials
Other Washington D.C. Clinical Trials
A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients with AIDS
|
|
|
|
|
|
|
|
