Search Clinical Trials
 
By Condition
 
By Location (USA)
 
By Location (Other)
 
By Sponsor
 
Resources
 
Privacy Policy
 
About Us
Disclaimer
A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections Clinical Trials Data presented on Clinical Trials Search is not meant to be a substitute for qualified health advice, visits or treatment with a real mD. We are not doctors. Always consult your doctor about A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections Clinical research trials and A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections healthcare trials happen in many of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectivity of new drugs. The purpose of the studies / projects is to solve particular human medical questions. Clinical trials are a popular way for doctors, government agencies, and private sector companies to discover cures for all varieties of conditions, such as A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections. A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections Clinical Trials and other clinical trials allow volunteers to have health treatment alternatives before they are available to the masses. Some times the human subjects obtain treatment for without cost, and sometimes they are compensated for their time. Occasionally there is a cost for a A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections clinical trial. Test subjects oftentimes receive the most effective healthcare possible for their A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections condition. Dangers are a reality, however, and may include extra or frequent physician visits, healthcare dangers (possibly life-jeopardising), and/or the treatment being uneffective. Trials are federally governed with rigorous guidelines to protect clinical trials patients.

Home > "A" Clinical Trials Conditions > A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections

A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections



A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections

For Condition: Mycoses,HIV Infections
Status: Completed
Sponsor(s): Pfizer ,
Synopsis: To compare the safety, tolerance and efficacy of fluconazole and amphotericin B as treatment for biopsy proven fungal infections in major organs, disseminated infection, suspected fungal infection and fungemia in adult neutropenic and non-neutropenic patients without AIDS, AIDS related complex (ARC), or extensive burns. HIV seropositive patients are allowed only if they also have a malignancy.
Details:
Eligibility:
Study Type:  Interventional, Treatment
Minimum Age/Maximum Age: 13 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Concurrent Medication: Allowed: - Immunostimulants under studies carried out under an IRB approved protocol. - Treatments of intercurrent non-fungal infection. - Allowed but requires monitoring during fluconazole therapy: - Barbiturates. - Phenytoin. - Oral hypoglycemics. - Coumarin-type anticoagulants. Patients must have the following: - Diagnosis or presumption of fungal infection under defined conditions. - Written informed consent either from the patient or the patient's legal guardian. Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: - Burns > 30 percent of the body. - Diagnosis of AIDS or AIDS related complex (ARC). - HIV positive unless they have a malignancy. - History of allergy to or intolerance of imidazoles or azoles. - Moderate to severe liver disease as defined by specific lab values. - Unlikely to survive more than 24 hours. - Evidence of previous amphotericin B sensitivity. Concurrent Medication: Excluded: - Concomitant antifungal agents other than the study drugs. - Immunostimulants, except for studies carried out under an IRB approved protocol. Concurrent Treatment: Excluded: - Lymphocyte replacements. Patients with the following are excluded: - Defined disease conditions listed in Exclusion Co-Existing Conditions. - Unlikely to survive more than 24 hours. - Previous participation in this study; reentry for the same infection is not allowed. - Known to be unable to take amphotericin B due to acute toxicities. Prior Medication: Excluded: - Previous fluconazole therapy for this infection.
Total Enrollment: 

Location and Contact Information:

Dr Layne Gentry
Houston,  Texas,  77030
United States
 

Dr Temple Williams
Houston,  Texas,  77030
United States
 

M D Anderson Cancer Ctr
Houston,  Texas,  77030
United States
 


Additional Information:
Study ID Numbers:  012N;  056-173
Study Start Date: 
Record last reviewed: December 1993
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002277

Other Hiv Infections Studies:
1. Safety and efficacy of BAY 50-4798 in patients with HIV infection

2. A Phase I/II Clinical Study of Nystatin I.V. (Intravenous) in Patients With HIV Infection.

3. Evaluation of the Interaction Between Acetaminophen and Zidovudine

4. Neurodevelopmental and Neurological Study of Infants and Children With HIV-1 Infection and AIDS in Clinical Trials

5. A Study to Evaluate the Effects of Giving IL-2 Alone to HIV-Positive Patients with CD4 Cell Counts of at Least 350 Cells/mm3 Who Do Not Wish to Receive Anti-HIV Therapy

Related Studies:

Other HIV Infections Clinical Trials
Other Texas Clinical Trials
Other Houston Clinical Trials

A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections
Modify your Search

  Other HIV Infections Clinical Trials
  Other Texas Clinical Trials
  Other Houston Clinical Trials


Warning: include(/var/www/cgi-bin/traxis/counter.php) [function.include]: failed to open stream: No such file or directory in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103

Warning: include() [function.include]: Failed opening '/var/www/cgi-bin/traxis/counter.php' for inclusion (include_path='.:/usr/local/lib/php') in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103